Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 7/20 | 0.53 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ME2 | P23368 | 1/20 | 0.43 |
| ▸ | ME1 | P48163 | 1/20 | 0.43 |
| ▸ | ME3 | Q16798 | 1/20 | 0.43 |
| ▸ | TYMS | P04818 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31087186 | 0.72 | ALDH1A1 (0.51) | GPBAR1FKBP1AKMT2AALDH1A1TSHR | |
| SCHEMBL10305162 | 0.69 | FKBP1A (0.76) | FKBP1AKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL22424056 | 0.69 | CLPP (0.56) | KDM4ESMN1; SMN2MAPTLMNAPKM | |
| SCHEMBL4990962 | 0.68 | SMN1; SMN2 (0.54) | KMT2AALDH1A1MEN1SMN1; SMN2NPC1 | |
| SCHEMBL28671519 | 0.68 | CLPP (0.44) | ALDH1A1KDM4ETSHRSMN1; SMN2MAPT | |
| SCHEMBL22424581 | 0.66 | CLPP (0.52) | KMT2ANPC1MAPTLMNAPKM | |
| SCHEMBL21064505 | 0.66 | ADORA2A (0.38) | KMT2AMEN1KDM4ETYMSSMN1; SMN2 | |
| SCHEMBL16099191 | 0.65 | FKBP1A (0.55) | GPBAR1FKBP1AKMT2AALDH1A1MEN1 | |
| SCHEMBL14218027 | 0.65 | FKBP1A (0.69) | FKBP1AKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL22410754 | 0.65 | P2RX3 (0.51) | ALDH1A1KDM4EHDAC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10308656-B2 | Small molecule inhibitors of Ku70/80 and uses thereof | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2019-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10308656-B2 | Small molecule inhibitors of Ku70/80 and uses thereof | XRCC6, XRCC5, RAD50 | GPBAR1 4644/4885FKBP1A 2217/4885KMT2A 1183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.