Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.64 |
| ▸ | MEN1 | O00255 | 6/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 6/20 | 0.62 |
| ▸ | RAB9A | P51151 | 6/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | ACP1 | P24666 | 1/20 | 0.61 |
| ▸ | CLK1 | P49759 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711380 | 0.86 | NPC1 (0.49) | ALDH1A1MEN1KMT2AHPGDNPC1 | |
| SCHEMBL4749080 | 0.83 | NPC1 (0.67) | ALDH1A1MEN1KMT2AHPGDNPC1 | |
| SCHEMBL29974741 | 0.82 | ALDH1A1 (0.64) | ALDH1A1MEN1KMT2AHPGDNPC1 | |
| SCHEMBL28878439 | 0.82 | ALDH1A1 (0.64) | ALDH1A1MEN1KMT2AHPGDNPC1 | |
| SCHEMBL28217860 | 0.80 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2AHPGDNPC1 | |
| SCHEMBL14189675 | 0.80 | NPC1 (0.61) | ALDH1A1MEN1KMT2AHPGDNPC1 | |
| SCHEMBL15376878 | 0.80 | ALDH1A1 (0.74) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL25464674 | 0.77 | RAB9A (0.60) | ALDH1A1MEN1KMT2AHPGDNPC1 | |
| SCHEMBL3022069 | 0.77 | ALDH1A1 (0.66) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL211763 | 0.77 | NPC1 (0.64) | ALDH1A1MEN1KMT2AHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |