Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.30 |
| ▸ | ME2 | P23368 | 1/20 | 0.30 |
| ▸ | ME1 | P48163 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21077861 | 0.89 | NAMPT (0.43) | GRM1GRM5MEN1KMT2ANAMPT | |
| SCHEMBL21077864 | 0.84 | JAK1 (0.40) | GRM1MEN1KMT2ANAMPTJAK2 | |
| SCHEMBL17886565 | 0.82 | GRM1 (0.45) | GRM1GRM5MEN1KMT2ANAMPT | |
| SCHEMBL17888233 | 0.82 | GRM1 (0.45) | GRM1GRM5MEN1KMT2ANAMPT | |
| SCHEMBL21252975 | 0.79 | GRM1 (0.43) | GRM1GRM5MEN1KMT2ANAMPT | |
| SCHEMBL21077998 | 0.79 | NAMPT (0.45) | GRM5MEN1KMT2ANAMPTCYP1A2 | |
| SCHEMBL21077810 | 0.78 | MEN1 (0.45) | MEN1KMT2ANAMPTJAK1CNR1 | |
| SCHEMBL21077993 | 0.77 | POLB (0.42) | MEN1KMT2ANAMPTCNR1 | |
| SCHEMBL21077996 | 0.76 | L3MBTL1 (0.45) | MEN1KMT2ANAMPT | |
| SCHEMBL18611164 | 0.75 | QDPR (0.47) | KMT2ANAMPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |