Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17888238 | 0.81 | NAMPT (0.43) | NAMPTMEN1KMT2ACYP1A2CHRM4 | |
| SCHEMBL17886557 | 0.78 | NAMPT (0.41) | NAMPTMEN1KMT2ACYP1A2CHRM4 | |
| SCHEMBL21077810 | 0.78 | MEN1 (0.45) | NAMPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL21077987 | 0.77 | PRSS1 (0.38) | GRM5JAK2JAK1PTGDR2 | |
| SCHEMBL21077998 | 0.75 | NAMPT (0.45) | NAMPTMEN1KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL21078112 | 0.75 | HPGD (0.42) | NAMPTKDM4EALDH1A1GRM5JAK2 | |
| SCHEMBL21077864 | 0.74 | JAK1 (0.40) | NAMPTMEN1KMT2AJAK2JAK1 | |
| SCHEMBL21077993 | 0.74 | POLB (0.42) | NAMPTMEN1KMT2AALDH1A1 | |
| SCHEMBL21077991 | 0.74 | ALDH1A1 (0.40) | MEN1KMT2AKDM4EALDH1A1JAK2 | |
| SCHEMBL21077807 | 0.74 | GRM1 (0.44) | NAMPTMEN1KMT2ACYP1A2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |