Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.38 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.38 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 5/20 | 0.32 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 3/20 | 0.32 |
| ▸ | BCL9 | O00512 | 1/20 | 0.32 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14242829 | 0.82 | SLC6A15 (0.39) | PRSS1TPSAB1TPSD1TPSG1JAK1 | |
| SCHEMBL21077854 | 0.81 | MAPT (0.43) | — | |
| SCHEMBL17886588 | 0.80 | BCL9 (0.37) | PRSS1TPSAB1TPSD1TPSG1JAK1 | |
| SCHEMBL21077999 | 0.78 | NOTUM (0.36) | JAK1JAK2GRM5 | |
| SCHEMBL21077858 | 0.78 | POLB (0.38) | JAK1JAK2GRM5SLC6A15 | |
| SCHEMBL21078142 | 0.77 | PRSS1 (0.35) | PRSS1TPSAB1TPSD1TPSG1JAK1 | |
| SCHEMBL21077859 | 0.77 | NAMPT (0.42) | JAK1JAK2PTGDR2GRM5 | |
| SCHEMBL21078141 | 0.77 | GRM5 (0.37) | JAK1JAK2GRM5 | |
| SCHEMBL21077805 | 0.77 | FAAH (0.37) | JAK1JAK2PTGDR2GRM5MGLL | |
| SCHEMBL21077916 | 0.77 | MEN1 (0.40) | JAK1JAK2PTGDR2SLC6A15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |