Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21077999 | 0.87 | NOTUM (0.36) | JAK2JAK1PRMT5WDR77 | |
| SCHEMBL21077854 | 0.84 | MAPT (0.43) | MEN1HPGDKMT2AALDH1A1TSHR | |
| SCHEMBL14243068 | 0.84 | MEN1 (0.40) | MEN1HPGDKMT2AKITRAB9A | |
| SCHEMBL19220891 | 0.82 | MEN1 (0.40) | MEN1HPGDKMT2AKITRAB9A | |
| SCHEMBL17886591 | 0.81 | MEN1 (0.39) | MEN1HPGDKMT2AKITRAB9A | |
| SCHEMBL21077858 | 0.81 | POLB (0.38) | SLC6A15ALDH1A1JAK2JAK1CHRM2 | |
| SCHEMBL3983201 | 0.79 | KMT2A (0.43) | MEN1HPGDKMT2AKITRAB9A | |
| SCHEMBL21078133 | 0.78 | L3MBTL1 (0.38) | MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL21077993 | 0.77 | POLB (0.42) | MEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL21078141 | 0.77 | GRM5 (0.37) | MEN1HPGDKMT2AALDH1A1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |