Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | SLC6A15 | Q9H2J7 | 2/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21077854 | 0.89 | MAPT (0.43) | POLBLMNASMN1; SMN2MAPTTDP1 | |
| SCHEMBL17888273 | 0.83 | SLC6A15 (0.39) | POLBLMNASMN1; SMN2CNR2SLC6A15 | |
| SCHEMBL21077916 | 0.81 | MEN1 (0.40) | SLC6A15JAK2JAK1ALDH1A1CHRM2 | |
| SCHEMBL11578372 | 0.81 | SMN1; SMN2 (0.37) | POLBLMNASMN1; SMN2CNR2SLC6A15 | |
| SCHEMBL17886577 | 0.81 | CNR2 (0.41) | POLBLMNASMN1; SMN2CNR2SLC6A15 | |
| SCHEMBL21078133 | 0.79 | L3MBTL1 (0.38) | SMN1; SMN2MAPTALDH1A1GRM5 | |
| SCHEMBL21077999 | 0.79 | NOTUM (0.36) | JAK2JAK1GRM5 | |
| SCHEMBL21077805 | 0.78 | FAAH (0.37) | POLBLMNASMN1; SMN2MAPTJAK2 | |
| SCHEMBL21077987 | 0.78 | PRSS1 (0.38) | SLC6A15JAK2JAK1GRM5 | |
| SCHEMBL21078141 | 0.78 | GRM5 (0.37) | POLBSMN1; SMN2MAPTJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |