Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17888221 | 0.82 | MAPT (0.39) | GRM5JAK2JAK1GAAMAPT | |
| SCHEMBL21077854 | 0.81 | MAPT (0.43) | GAAMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL17886538 | 0.80 | GRM5 (0.37) | GRM5JAK2JAK1GAAMAPT | |
| SCHEMBL21077999 | 0.78 | NOTUM (0.36) | GRM5JAK2JAK1 | |
| SCHEMBL21077858 | 0.78 | POLB (0.38) | GRM5JAK2JAK1GAAMAPT | |
| SCHEMBL21077991 | 0.77 | ALDH1A1 (0.40) | JAK2JAK1GAAMAPTKDM4E | |
| SCHEMBL21077987 | 0.77 | PRSS1 (0.38) | GRM5JAK2JAK1 | |
| SCHEMBL21077916 | 0.77 | MEN1 (0.40) | JAK2JAK1ALDH1A1MEN1HPGD | |
| SCHEMBL21077805 | 0.77 | FAAH (0.37) | GRM5JAK2JAK1GAAMAPT | |
| SCHEMBL21078127 | 0.75 | MEN1 (0.40) | JAK2JAK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |