Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 2/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 3/20 | 0.35 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.32 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.32 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14040492 | 0.91 | CHRM2 (0.46) | TSHRSIGMAR1CHRM2S1PR2S1PR1 | |
| SCHEMBL3456909 | 0.91 | CHRM2 (0.46) | TSHRSIGMAR1CHRM2S1PR2S1PR1 | |
| SCHEMBL4640467 | 0.84 | TSHR (0.46) | TSHRSIGMAR1CHRM2S1PR2S1PR1 | |
| SCHEMBL6400745 | 0.83 | TSHR (0.48) | TSHRSIGMAR1CHRM2S1PR2S1PR1 | |
| SCHEMBL11586877 | 0.83 | TSHR (0.48) | TSHRSIGMAR1CHRM2S1PR2S1PR1 | |
| SCHEMBL3456784 | 0.82 | TSHR (0.52) | TSHRDNM1ZDHHC20ZDHHC2 | |
| SCHEMBL11668526 | 0.81 | — | — | |
| SCHEMBL18281275 | 0.81 | TSHR (0.48) | TSHRSIGMAR1CHRM2 | |
| SCHEMBL2827056 | 0.81 | CHRM2 (0.38) | TSHRCHRM2S1PR2S1PR1S1PR3 | |
| Hydrochloric Acid SCHEMBL5595409 | 0.81 | DNM1 (0.48) | TSHRSIGMAR1CHRM2S1PR2S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |