Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28553118 | 0.79 | MAPT (0.39) | CHRNA7SIGMAR1LMNAHTR3EHTR3B | |
| SCHEMBL17888252 | 0.76 | CHRNA7 (0.46) | CHRNA7SIGMAR1LMNAHTR3EHTR3B | |
| SCHEMBL11834602 | 0.76 | CHRNA7 (0.41) | CHRNA7SIGMAR1LMNAHTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL1596638 | 0.74 | DRD4 (0.50) | SIGMAR1DRD4DRD2ALOX15HTR1A | |
| SCHEMBL13945550 | 0.72 | ALDH1A1 (0.42) | CHRNA7SIGMAR1LMNAHTR3EHTR3B | |
| SCHEMBL7516695 | 0.72 | CHRNA7 (0.42) | CHRNA7SIGMAR1LMNAHTR3EHTR3B | |
| SCHEMBL8780579 | 0.71 | LTA4H (0.44) | CHRNA7SIGMAR1LMNAHTR3EHTR3B | |
| SCHEMBL10263391 | 0.71 | LMNA (0.58) | SIGMAR1LMNADRD4MEN1POLB | |
| SCHEMBL1889513 | 0.70 | LMNA (0.46) | CHRNA7SIGMAR1LMNAHTR3EHTR3B | |
| SCHEMBL164538 | 0.67 | LMNA (0.67) | CHRNA7SIGMAR1LMNAHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |