Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL684582 | 0.81 | OPRD1 (0.62) | OPRD1OPRM1DRD4GRIN2DGRIN3B | |
| SCHEMBL21078015 | 0.80 | DRD2 (0.45) | OPRM1DRD4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL498014 | 0.79 | OPRM1 (0.50) | OPRM1DRD4OPRL1OPRK1ALDH1A1 | |
| Methyl Alcohol SCHEMBL11452306 | 0.78 | OPRD1 (0.64) | OPRD1OPRM1DRD4KCNH2CHRM1 | |
| Ammonia Solution, Strong SCHEMBL9556021 | 0.77 | OPRM1 (0.48) | OPRM1DRD4OPRL1OPRK1ALDH1A1 | |
| SCHEMBL10819383 | 0.76 | OPRM1 (0.58) | OPRD1OPRM1KCNH2OPRL1OPRK1 | |
| SCHEMBL8145308 | 0.76 | OPRM1 (0.70) | OPRD1OPRM1DRD4GRIN2DGRIN3B | |
| SCHEMBL19998529 | 0.76 | CYP2D6 (0.70) | OPRD1OPRM1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL21077926 | 0.75 | OPRL1 (0.58) | OPRD1OPRM1OPRL1OPRK1SIGMAR1 | |
| SCHEMBL21077986 | 0.75 | GRM2 (0.39) | OPRD1OPRM1DRD4GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022125925-A1 | COMPOSITIONS FOR TREATING DRY AGE-RELATED MACULAR DEGENERATION (AMD) | COGNITION THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |