Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.44 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10724025 | 0.89 | AKR1C3 (0.58) | AKR1C3HPGDPOLBGAAL3MBTL3 | |
| SCHEMBL10720569 | 0.79 | AKR1C3 (0.60) | AKR1C3L3MBTL3HDAC3HDAC4HDAC1 | |
| SCHEMBL10724005 | 0.76 | HPGD (0.52) | HPGDPOLBGAAL3MBTL3HDAC3 | |
| SCHEMBL19479127 | 0.74 | DRD3 (0.64) | HPGDPOLBGAAKMT2AMEN1 | |
| SCHEMBL10724903 | 0.73 | HDAC3 (0.56) | HPGDPOLBL3MBTL3HDAC3HDAC4 | |
| SCHEMBL395217 | 0.72 | POLB (0.63) | HPGDPOLBL3MBTL3KMT2AMEN1 | |
| SCHEMBL23884836 | 0.72 | AKR1C3 (0.47) | AKR1C3L3MBTL3HDAC3HDAC4HDAC1 | |
| SCHEMBL4900673 | 0.72 | HPGD (0.71) | HPGDL3MBTL3KMT2AMEN1 | |
| SCHEMBL28204197 | 0.71 | AKR1C3 (0.49) | AKR1C3TEAD1TEAD3KMT2AMEN1 | |
| SCHEMBL10720264 | 0.71 | HPGD (0.59) | HPGDL3MBTL3HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |