Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 11/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | STK25 | O00506 | 1/20 | 0.41 |
| ▸ | CIT | O14578 | 1/20 | 0.41 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4900673 | 0.82 | HPGD (0.71) | HPGDALDH1A1LMNAHTTL3MBTL3 | |
| SCHEMBL4906405 | 0.79 | PHGDH (0.63) | HPGDALDH1A1HTTKDM4EPOLB | |
| SCHEMBL3583338 | 0.77 | HPGD (0.73) | HPGDALDH1A1SIGMAR1L3MBTL3L3MBTL1 | |
| SCHEMBL15653359 | 0.72 | SIGMAR1 (0.57) | HPGDALDH1A1SIGMAR1L3MBTL3L3MBTL1 | |
| SCHEMBL8358137 | 0.72 | SIGMAR1 (0.81) | HPGDALDH1A1SIGMAR1L3MBTL3L3MBTL1 | |
| SCHEMBL15172602 | 0.72 | SIGMAR1 (0.64) | HPGDALDH1A1SIGMAR1L3MBTL3L3MBTL1 | |
| SCHEMBL7132525 | 0.69 | HPGD (1.00) | HPGDALDH1A1LMNAL3MBTL3L3MBTL1 | |
| SCHEMBL27479149 | 0.69 | HPGD (1.00) | HPGDALDH1A1LMNAL3MBTL3L3MBTL1 | |
| Tetrahydrofuran SCHEMBL9241644 | 0.69 | TAS1R3 (0.38) | HPGDALDH1A1KDM4EL3MBTL1PHGDH | |
| SCHEMBL12812076 | 0.69 | SIGMAR1 (0.39) | HPGDALDH1A1SIGMAR1POLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |