Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30323375 | 0.78 | MAPK1 (0.49) | MAPK1KMT2AMEN1POLBLMNA | |
| SCHEMBL18740086 | 0.77 | PLAT (0.40) | MAPK1TSHRPOLBTP53PLAT | |
| SCHEMBL30323467 | 0.76 | BRD4 (0.45) | MAPK1KMT2AMEN1 | |
| SCHEMBL23414986 | 0.74 | ALDH1A1 (0.48) | MAPK1KMT2AMEN1TSHRTP53 | |
| SCHEMBL31714739 | 0.74 | ALDH1A1 (0.45) | MAPK1KMT2AMEN1POLBLMNA | |
| SCHEMBL18740020 | 0.73 | PLAT (0.42) | MAPK1POLBALDH1A1PLATNPC1 | |
| SCHEMBL29852457 | 0.72 | ALDH1A1 (0.44) | MAPK1KMT2AMEN1POLBTP53 | |
| SCHEMBL18740351 | 0.71 | NOX4 (0.39) | MAPK1KMT2AMEN1POLBLMNA | |
| SCHEMBL31053388 | 0.70 | ALDH1A1 (0.42) | MAPK1KMT2AMEN1POLBTP53 | |
| SCHEMBL31158416 | 0.69 | MAPK1 (0.42) | MAPK1KMT2AMEN1POLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10316040-B2 | EP4 antagonists | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2019-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10316040-B2 | EP4 antagonists | PTGER4, PTGER3, PTGER1 | MAPK1 1927/4885KMT2A 3284/4885MEN1 1667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.