Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2108196 | 1.00 | LMNA (0.32) | LMNACYP2D6HTR2ASLC6A4KCNH2 | |
| SCHEMBL2108263 | 1.00 | LMNA (0.32) | LMNACYP2D6HTR2ASLC6A4KCNH2 | |
| SCHEMBL2108265 | 1.00 | LMNA (0.32) | LMNACYP2D6HTR2ASLC6A4KCNH2 | |
| SCHEMBL1644908 | 0.76 | CYP3A4 (0.31) | — | |
| SCHEMBL1285918 | 0.74 | ALDH1A1 (0.34) | LMNAALDH1A1 | |
| SCHEMBL1285917 | 0.74 | ALDH1A1 (0.34) | LMNAALDH1A1 | |
| SCHEMBL30239598 | 0.74 | CA1 (0.46) | CYP2D6HTR2ASLC6A4KCNH2ALDH1A1 | |
| SCHEMBL1893420 | 0.73 | LMNA (0.46) | LMNAHTR2ASLC6A4KCNH2 | |
| SCHEMBL3851152 | 0.73 | KMT2A (0.36) | LMNAHTR2ASLC6A4KCNH2ALDH1A1 | |
| SCHEMBL13608097 | 0.73 | KMT2A (0.36) | LMNAHTR2ASLC6A4KCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158650-B2 | Substituted phenylmethyl bicyclocarboxyamide compounds | PFIZER INC. (US) | 2012-04-17 | — | — | US | disclosed |
| EP-2222631-B1 | SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | PFIZER (US) | 2011-08-17 | — | — | EP | disclosed |
| US-20100087480-A1 | SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | PFIZER INC. | 2010-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087480-A1 | SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | TRPV1, P2RY1, TRPV2 | LMNA 1220/4885CYP2D6 2289/4885HTR2A 456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.