Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 8/20 | 0.57 |
| ▸ | PIM1 | P11309 | 8/20 | 0.57 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2107212 | 0.88 | NTRK1 (0.60) | NTRK1PIM1ACVR1MAPTKDM4E | |
| SCHEMBL2108181 | 0.84 | NTRK1 (0.57) | NTRK1PIM1ACVR1MAPTKDM4E | |
| SCHEMBL4481713 | 0.83 | NTRK1 (0.38) | NTRK1PIM1ACVR1KDM4EALDH1A1 | |
| SCHEMBL1688835 | 0.81 | SMN1; SMN2 (0.52) | MAPTKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL2106919 | 0.74 | NTRK1 (0.60) | NTRK1PIM1ACVR1MAPTKDM4E | |
| SCHEMBL2107736 | 0.73 | L3MBTL1 (0.37) | MAPTKDM4EALDH1A1POLBNPC1 | |
| SCHEMBL9728923 | 0.71 | NTRK1 (0.80) | NTRK1PIM1ACVR1MAPTKDM4E | |
| SCHEMBL29283642 | 0.70 | NTRK1 (0.81) | NTRK1PIM1ACVR1MAPTKDM4E | |
| SCHEMBL11472391 | 0.70 | NTRK1 (0.68) | NTRK1PIM1ACVR1MAPTKDM4E | |
| SCHEMBL2107084 | 0.69 | SMN1; SMN2 (0.52) | NTRK1PIM1ACVR1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158632-B2 | Pyrazolo[1,5-a]pyrimidines, processes, uses and compositions | FERRER INTERNACIONAL, S.A. (ES) | 2012-04-17 | — | — | US | claimed |
| EP-2059521-B1 | PYRAZOLO[1,5-A]PYRIMIDINES, PROCESSES, USES AND COMPOSITIONS | FERRER INT (ES) | 2010-06-02 | — | — | EP | claimed |
| EP-1884516-A1 | Pyrazolo[1,5-a]pyrimidines, processes, uses and compositions | FERRER INTERNACIONAL, S.A. (ES) | 2008-02-06 | — | — | EP | claimed |
| US-8158632-B2 | Pyrazolo[1,5-a]pyrimidines, processes, uses and compositions | FERRER INTERNACIONAL, S.A. (ES) | 2012-04-17 | — | — | US | disclosed |
| EP-2059521-B1 | PYRAZOLO[1,5-A]PYRIMIDINES, PROCESSES, USES AND COMPOSITIONS | FERRER INT (ES) | 2010-06-02 | — | — | EP | disclosed |
| US-20090264448-A1 | PYRAZOLO[1,5-A]PYRIMIDINES, PROCESSES, USES AND COMPOSITIONS | FERRER INTERNATIONAL, S.A. (ES) | 2009-10-22 | — | — | US | disclosed |
| EP-2059521-A1 | PYRAZOLO[1,5-A]PYRIMIDINES, PROCESSES, USES AND COMPOSITIONS | Ferrer Internacional, S.A. (ES) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008015253-A1 | PYRAZOLO[1,5-A]PYRIMIDINES, PROCESSES, USES AND COMPOSITIONS | FERRER INTERNACIONAL, S.A. (ES) | 2008-02-07 | — | — | WO | disclosed |
| EP-1884516-A1 | Pyrazolo[1,5-a]pyrimidines, processes, uses and compositions | FERRER INTERNACIONAL, S.A. (ES) | 2008-02-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264448-A1 | PYRAZOLO[1,5-A]PYRIMIDINES, PROCESSES, USES AND COMPOSITIONS | P2RX5, GABRA5, P2RX1 | NTRK1 1866/4885PIM1 2058/4885ACVR1 1705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.