Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8803746 | 0.84 | KDM4E (0.51) | CYP11B1KDM4EMAPTHPGDKMT2A | |
| SCHEMBL8804838 | 0.79 | NPC1 (0.48) | CYP11B1KDM4EMAPTHPGDTLR8 | |
| SCHEMBL9076409 | 0.78 | MAPT (0.49) | CYP11B1MAPTPOLBTDP1TP53 | |
| SCHEMBL12086447 | 0.77 | CYP11B1 (0.44) | CYP11B1KDM4EMAPTHPGDHSD11B1 | |
| SCHEMBL929363 | 0.76 | CYP11B1 (0.49) | CYP11B1KDM4EMAPTHPGDHSD11B1 | |
| SCHEMBL363772 | 0.74 | — | — | |
| SCHEMBL2107335 | 0.74 | DPP4 (0.45) | KDM4EMAPTHPGDHSD11B1FABP4 | |
| SCHEMBL1007759 | 0.73 | CYP11B1 (0.53) | CYP11B1KDM4EMAPTHSD11B1POLB | |
| SCHEMBL27046001 | 0.73 | CYP11B1 (0.47) | CYP11B1KDM4EHPGDHSD11B1KMT2A | |
| SCHEMBL4061725 | 0.73 | LMNA (0.44) | CYP11B1KDM4EKMT2ANPSR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912986-B1 | IMIDIAZO -AND TRIAZOLOPYRIDINES AS INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I | BRISTOL MYERS SQUIBB CO (US) | 2012-09-05 | — | — | EP | disclosed |
| US-8158648-B2 | Heteroaryl 11-beta hydroxysteroid dehydrogenase type I inhibitors | LI JAMES J (US) | 2012-04-17 | — | — | US | disclosed |
| US-8158648-B2 | Heteroaryl 11-beta hydroxysteroid dehydrogenase type I inhibitors | LI JAMES J (US) | 2012-04-17 | — | — | US | disclosed |
| US-8158648-B2 | Heteroaryl 11-beta hydroxysteroid dehydrogenase type I inhibitors | LI JAMES J (US) | 2012-04-17 | — | — | US | disclosed |
| US-20090306084-A1 | HETEROARYL 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2009-12-10 | — | — | US | disclosed |
| US-20090306084-A1 | HETEROARYL 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2009-12-10 | — | — | US | disclosed |
| US-20090306084-A1 | HETEROARYL 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2009-12-10 | — | — | US | disclosed |
| US-7572807-B2 | Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-11 | — | — | US | disclosed |
| US-7572807-B2 | Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-11 | — | — | US | disclosed |
| US-7572807-B2 | Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-11 | — | — | US | disclosed |
| EP-1912986-A1 | IMIDIAZO -AND TRIAZOLOPYRIDINES AS INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I | Brystol-Myers Squibb Company (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2006135667-A1 | IMIDIAZO -AND TRIAZOLOPYRIDINES AS INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-12-21 | — | — | WO | disclosed |
| US-20060281750-A1 | Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2006-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306084-A1 | HETEROARYL 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS | HSD11B1, HSD17B1, HSD11B2 | CYP11B1 22/4885KDM4E 4175/4885MAPT 3871/4885 |
| US-20060281750-A1 | Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors | HSD11B1, HSD17B1, HSD11B2 | CYP11B1 20/4885KDM4E 4239/4885MAPT 3816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.