Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 4/20 | 0.35 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1190555 | 0.89 | — | — | |
| SCHEMBL5831087 | 0.89 | JAK1 (0.39) | JAK1JAK2TYK2JAK3DPP4 | |
| SCHEMBL21089261 | 0.83 | JAK1 (0.36) | JAK1JAK2TYK2JAK3DPP4 | |
| SCHEMBL6977767 | 0.80 | — | — | |
| SCHEMBL2751529 | 0.80 | SMN1; SMN2 (0.39) | JAK1JAK2DPP4 | |
| SCHEMBL15014481 | 0.79 | ALDH1A1 (0.38) | JAK1JAK2TYK2JAK3DPP4 | |
| SCHEMBL21782065 | 0.79 | ALDH1A1 (0.38) | JAK1JAK2TYK2JAK3DPP4 | |
| SCHEMBL21781847 | 0.79 | JAK1 (0.38) | JAK1JAK2TYK2JAK3DPP4 | |
| SCHEMBL6160369 | 0.78 | DPP4 (0.40) | DPP4 | |
| SCHEMBL3167403 | 0.78 | DPP4 (0.40) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3617221-A1 | CYTOTOXIN AND CONJUGATE, USES OF SAME, AND PREPARATION METHOD THEREFOR | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2020-03-04 | — | — | EP | disclosed |
| WO-2013007768-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF AS JAK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-01-17 | — | — | WO | disclosed |
| US-5344846-A | Administering aminoalkylguanidine; antitumor agents | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1994-09-06 | — | — | US | disclosed |
| WO-1994015596-A1 | COMPOSITIONS AND METHODS FOR INHIBITING DEOXYHYPUSINE SYNTHASE AND THE GROWTH OF CELLS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1994-07-21 | — | — | WO | disclosed |