Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | LPL | P06858 | 1/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20078160 | 0.79 | LPL (0.38) | LPLLIPG | |
| SCHEMBL21090361 | 0.79 | ESR1 (0.40) | ESR1THRATHRBLPLLIPG | |
| SCHEMBL890386 | 0.79 | LPL (0.40) | ESR1LPLLIPG | |
| SCHEMBL3686725 | 0.78 | — | — | |
| SCHEMBL25379713 | 0.76 | TRPA1 (0.34) | LPLLIPG | |
| SCHEMBL14986010 | 0.76 | CHKA (0.35) | LPLLIPG | |
| SCHEMBL19865446 | 0.75 | ALDH1A1 (0.39) | ESR1 | |
| SCHEMBL11887577 | 0.74 | LPL (0.47) | ESR1LPLLIPG | |
| SCHEMBL14790147 | 0.73 | LPL (0.61) | ESR1LPLLIPG | |
| SCHEMBL7591877 | 0.72 | ACHE (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11576979-B2 | Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof | GENENTECH, INC. (US) | 2023-02-14 | — | — | US | disclosed |
| US-20190175749-A1 | PYRROLOBENZODIAZEPINE PRODRUGS AND ANTIBODY CONJUGATES THEREOF | GENENTECH, INC. (US) | 2019-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190175749-A1 | PYRROLOBENZODIAZEPINE PRODRUGS AND ANTIBODY CONJUGATES THEREOF | NQO1, GSTP1, CYBB | ESR1 906/4885THRA 3263/4885THRB 1735/4885 |
| US-11576979-B2 | Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof | NQO1, GSTP1, CYBB | ESR1 906/4885THRA 3263/4885THRB 1735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.