Oleandomycin

Oleandomycin

SCHEMBL950913

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nearest known ligand 0.96

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Oleandomycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 12/20 0.96
LMNA P02545 3/20 0.96
ABCB1 P08183 3/20 0.71
USP2 O75604 2/20 0.71
MLNR O43193 4/20 0.43
KCNH2 Q12809 5/20 0.43
AR P10275 1/20 0.43
MAPK1 P28482 1/20 0.43
SLCO1B3 Q9NPD5 1/20 0.43
SLCO1B1 Q9Y6L6 1/20 0.43
TSHR P16473 2/20 0.42
TDP1 Q9NUW8 1/20 0.42
ALB P02768 1/20 0.42
CNR1 P21554 1/20 0.42
HTR2A P28223 1/20 0.42
AOX1 Q06278 1/20 0.42
CYP1B1 Q16678 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Oleandomycin SCHEMBL3717 0.98 CYP3A4 (1.00) CYP3A4LMNAABCB1USP2MLNR
Oleandomycin SCHEMBL10028439 0.98 CYP3A4 (1.00) CYP3A4LMNAABCB1USP2MLNR
Oleandomycin SCHEMBL3716 0.98 CYP3A4 (1.00) CYP3A4LMNAABCB1USP2MLNR
Oleandomycin SCHEMBL9807053 0.97 CYP3A4 (0.99) CYP3A4LMNAABCB1USP2MLNR
Oleandomycin SCHEMBL285338 0.95 CYP3A4 (1.00) CYP3A4LMNAABCB1USP2MLNR
Oleandomycin SCHEMBL5033021 0.95 CYP3A4 (1.00) CYP3A4LMNAABCB1USP2MLNR
SCHEMBL11029029 0.90 CYP3A4 (0.85) CYP3A4LMNAABCB1USP2MLNR
Diproleandomycin SCHEMBL2109038 0.86 CYP3A4 (0.78) CYP3A4LMNAABCB1USP2MLNR
SCHEMBL5551907 0.84 CYP3A4 (0.74) CYP3A4LMNAABCB1USP2MLNR
Troleandomycin SCHEMBL664623 0.83 CYP3A4 (1.00) CYP3A4LMNAABCB1USP2MLNR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260027191-A1 COMPOSITIONS AND METHODS FOR TREATING BACTERIAL DISEASE UNIV ARIZONA (US) 2026-01-29 US disclosed
EP-4628100-A2 ANTI-VIRAL COMPOUNDS AND METHODS FOR ADMINISTRATION THEREOF Gregg, John Malcolm Hall (US) 2025-10-08 EP disclosed
US-12285413-B2 Anti-viral agents and methods for administration thereof GREGG JOHN M H (US) 2025-04-29 US disclosed
US-20250099566-A1 COMPOSITIONS AND METHODS FOR TREATING BACTERIAL DISEASE NATIONAL INSTITUTES OF HEALTH 2025-03-27 US disclosed
US-20240173456-A1 THERAPEUTIC COMPOSITIONS FOR WOUND TREATMENT ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY 2024-05-30 US disclosed
WO-2023201345-A2 COMPOSITIONS AND METHODS FOR TREATING BACTERIAL DISEASE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2023-10-19 WO disclosed
US-20230263778-A1 ANTI-VIRAL COMPOUNDS AND METHODS FOR ADMINISTRATION THEREOF GREGG JOHN M H (US) 2023-08-24 US disclosed
WO-2023137320-A2 COMPOSITIONS AND METHODS FOR TREATING BACTERIAL DISEASE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2023-07-20 WO disclosed
US-20230201167-A1 ANTI-VIRAL AGENTS AND METHODS FOR ADMINISTRATION THEREOF GREGG JOHN M H (US) 2023-06-29 US disclosed
EP-4110330-A1 ANTI-VIRAL COMPOUNDS AND METHODS FOR ADMINISTRATION THEREOF Gregg, John Malcolm Hall (US) 2023-01-04 EP disclosed
EP-2346516-A2 ANTIMICROBIAL COMPOSITION FROM COPEPODS Nofima Ingrediens (NO) 2011-07-27 EP disclosed
US-20110021964-A1 Device for Promotion of Hemostasis and/or Wound Healing Ferrosan Medical Devices A/S (DK) 2011-01-27 US disclosed
EP-2259803-A2 DEVICE FOR PROMOTION OF HEMOSTASIS AND/OR WOUND HEALING Ferrosan Medical Devices A/S (DK) 2010-12-15 EP disclosed
WO-2010049454-A2 ANTIMICROBIAL COMPOSITION FROM COPEPODS NOFIMA INGREDIENS (NO) 2010-05-06 WO disclosed
WO-2010009735-A2 COMBINATORIAL ANALYSIS AND REPAIR DAKO DENMARK A/S (DK) 2010-01-28 WO disclosed
WO-2009109194-A2 DEVICE FOR PROMOTION OF HEMOSTASIS AND/OR WOUND HEALING FERROSAN A/S (DK) 2009-09-11 WO disclosed
EP-1904041-A2 NANOPARTICULATE CLARITHROMYCIN FORMULATIONS Elan Pharma International Limited (IE) 2008-04-02 EP disclosed
WO-2007008537-A2 NANOPARTICULATE CLARITHROMYCIN FORMULATIONS ELAN PHARMA INTERNATIONAL, LIMITED (IE) 2007-01-18 WO disclosed
US-20070015719-A1 Nanoparticulate clarithromycin formulations ELAN PHARMA INTERNATIONAL LIMITED 2007-01-18 US disclosed
WO-2001092288-A2 COBALAMIN COMPOUNDS USEFUL AS ANTIBIOTIC AGENTS AND AS IMAGING AGENTS MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2001-12-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230263778-A1 ANTI-VIRAL COMPOUNDS AND METHODS FOR ADMINISTRATION THEREOF ACE2, ACE, SARS1 CYP3A4 741/4885LMNA 1742/4885ABCB1 172/4885
US-20070015719-A1 Nanoparticulate clarithromycin formulations NPC1, NPC1L1, HDAC6 CYP3A4 27/4885LMNA 3568/4885ABCB1 16/4885
US-20260027191-A1 COMPOSITIONS AND METHODS FOR TREATING BACTERIAL DISEASE DNMT3L, DNMT3A, DNMT1 CYP3A4 3633/4885LMNA 1451/4885ABCB1 375/4885
US-12285413-B2 Anti-viral agents and methods for administration thereof ACE2, ACE, MAVS CYP3A4 754/4885LMNA 2369/4885ABCB1 253/4885
US-20230201167-A1 ANTI-VIRAL AGENTS AND METHODS FOR ADMINISTRATION THEREOF ACE2, ACE, MAVS CYP3A4 754/4885LMNA 2369/4885ABCB1 253/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.