Broxaldine

Broxaldine

SCHEMBL2109050

Cc1ccc2c(Br)cc(Br)c(OC(=O)c3ccccc3)c2n1

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.41
MAPT P10636 5/20 0.41
LMNA P02545 4/20 0.41
GAA P10253 3/20 0.41
HTT P42858 2/20 0.41
KDM4E B2RXH2 2/20 0.41
POLB P06746 1/20 0.41
PKM P14618 1/20 0.41
METAP2 P50579 1/20 0.39
METAP1 P53582 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
KMT2A Q03164 6/20 0.39
MEN1 O00255 2/20 0.39
PTBP1 P26599 1/20 0.39
RECQL P46063 1/20 0.39
RAB9A P51151 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
TDP1 Q9NUW8 1/20 0.38
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Broxaldine SCHEMBL29888411 1.00 ALOX5 (0.41) ALOX5MAPTLMNAGAAHTT
SCHEMBL18106114 0.90 GAA (0.38) ALOX5MAPTGAAHTTKDM4E
SCHEMBL18106122 0.82 KDM4E (0.42) MAPTGAAHTTKDM4EPKM
SCHEMBL9951316 0.81 KDM4E (0.49) MAPTLMNAGAAHTTKDM4E
SCHEMBL18106119 0.81 MAPT (0.45) MAPTLMNAGAAHTTKDM4E
SCHEMBL16862273 0.77 NQO2 (0.59) MAPTLMNAHTTKDM4EMETAP2
SCHEMBL7690476 0.74 NQO2 (0.50) MAPTLMNAGAAHTTKDM4E
SCHEMBL9956727 0.74 PARP1 (0.37) MAPTLMNAGAAHTTKDM4E
SCHEMBL18294117 0.73 NQO2 (0.57) MAPTLMNAKMT2AMEN1RAB9A
SCHEMBL16867454 0.73 NQO2 (0.57) MAPTGAAPKMKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3803402-B1 ANTI-CANCER TREATMENT OF PRESELECTED SUBJECTS AND SCREENING METHODS TO IDENTIFY SUSCEPTIBLE SUBJECTS TUDAG TU DRESDEN AG (DE) 2023-04-26 EP claimed
EP-3829640-A1 METHODS FOR INHIBITING MICROBE GROWTH McMaster University (CA) 2021-06-09 EP claimed
US-20200325543-A1 DIAGNOSTIC METHOD TOLREMO THERAPEUTICS AG (CH) 2020-10-15 US claimed
EP-3714069-A1 DIAGNOSTIC METHOD Tolremo Therapeutics AG (CH) 2020-09-30 EP claimed
WO-2020024060-A1 METHODS FOR INHIBITING MICROBE GROWTH MCMASTER UNIVERSITY (CA) 2020-02-06 WO claimed
US-10184933-B2 Compositions, systems and methods for gene expression noise drug screening and uses thereof The J. David Gladstone Industries (US) 2019-01-22 US claimed
US-20160245796-A1 COMPOSITIONS, SYSTEMS AND METHODS FOR GENE EXPRESSION NOISE DRUG SCREENING AND USES THEREOF THE J. DAVID GLADSTONE INSTITUTES (US) 2016-08-25 US claimed
EP-3052662-A1 COMPOSITIONS, SYSTEMS AND METHODS FOR GENE EXPRESSION NOISE DRUG SCREENING AND USES THEREOF The J. David Gladstone Institutes (US) 2016-08-10 EP claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
WO-2015051035-A1 COMPOSITIONS, SYSTEMS AND METHODS FOR GENE EXPRESSION NOISE DRUG SCREENING AND USES THEREOF THE J. DAVID GLADSTONE INSTITUTES (US) 2015-04-09 WO claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
US-12590963-B2 Anti-cancer treatment of preselected subjects and screening methods to identify susceptible subjects TUDAG TU DRESDEN AKTIENGESELLSCHAFT (DE) 2026-03-31 US disclosed
EP-3803402-B1 ANTI-CANCER TREATMENT OF PRESELECTED SUBJECTS AND SCREENING METHODS TO IDENTIFY SUSCEPTIBLE SUBJECTS TUDAG TU DRESDEN AG (DE) 2023-04-26 EP disclosed
US-6331289-B1 ULTRASOUND CONTRAST AGENTS, SUSPENSION IN AQUEOUS CARRIER LIQUID OF A REPORTER COMPRISING GAS-CONTAINING OR GAS-GENERATING MATERIAL, AGENT CAPABLE OF FORMING AT LEAST TWO TYPES OF BINDING PAIRS WITH TARGET; REPORTER BEING CONJUGATED NYCOMED IMAGING AS (NO) 2001-12-18 US disclosed
US-6264917-B1 MIXTURE OF GAS FILLED MICROBUBBLES AND RELEASING AGENT NYCOMED IMAGING AS (NO) 2001-07-24 US disclosed
US-6261537-B1 TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES NYCOMED IMAGING AS (NO) 2001-07-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12590963-B2 Anti-cancer treatment of preselected subjects and screening methods to identify susceptible subjects TPM4, TPM3, TAGLN2 ALOX5 647/4885MAPT 3135/4885LMNA 584/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.