Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 5/20 | 0.43 |
| ▸ | TDO2 | P48775 | 4/20 | 0.43 |
| ▸ | METAP2 | P50579 | 3/20 | 0.41 |
| ▸ | METAP1 | P53582 | 3/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14754342 | 0.81 | CASP6 (0.48) | CASP6IDO1TDO2METAP2METAP1 | |
| SCHEMBL4533718 | 0.78 | CASP6 (0.45) | CASP6IDO1TDO2METAP2METAP1 | |
| SCHEMBL29430087 | 0.77 | METAP2 (0.46) | IDO1TDO2METAP2METAP1TSHR | |
| SCHEMBL4533675 | 0.77 | METAP2 (0.46) | IDO1TDO2METAP2METAP1TSHR | |
| SCHEMBL21777129 | 0.75 | IDO1 (0.45) | CASP6IDO1TDO2TDP1KDM4A | |
| SCHEMBL31469002 | 0.75 | MKNK1 (0.52) | TDO2PDE2APDE4DPDE3APDE10A | |
| SCHEMBL3421959 | 0.75 | MKNK1 (0.52) | TDO2PDE2APDE4DPDE3APDE10A | |
| SCHEMBL26259974 | 0.74 | SCN9A (0.43) | CASP6IDO1TDO2METAP2METAP1 | |
| SCHEMBL10151023 | 0.73 | MPL (0.50) | CASP6IDO1TDO2METAP2METAP1 | |
| SCHEMBL27545633 | 0.73 | METAP1 (0.40) | CASP6IDO1TDO2METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3495358-A1 | AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | Bristol-Myers Squibb Company (US) | 2019-06-12 | — | — | EP | disclosed |