Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21092019 | 0.87 | ALOX15 (0.46) | ESR1ESR2MEN1KMT2AALDH1A1 | |
| SCHEMBL20856119 | 0.80 | CYP19A1 (0.51) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL11750596 | 0.75 | CYP1A2 (0.48) | ALDH1A1HPGDCYP1A2KDM4E | |
| SCHEMBL11749703 | 0.75 | MAPK1 (0.63) | MEN1KMT2AALDH1A1CYP1A2POLB | |
| SCHEMBL6479522 | 0.74 | PIK3CA (0.37) | — | |
| SCHEMBL11752378 | 0.74 | GABRA1 (0.34) | ESR1ESR2CYP1A2MAPT | |
| SCHEMBL11752698 | 0.74 | MAPK1 (0.41) | MEN1KMT2AKDM4EMAPT | |
| SCHEMBL11726825 | 0.74 | CYP19A1 (0.38) | PPARD | |
| SCHEMBL11754929 | 0.74 | ABL1 (0.35) | ESR1ESR2 | |
| SCHEMBL11752049 | 0.73 | MAPK1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817299-B1 | SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LTD (IN) | 2019-06-12 | — | — | EP | disclosed |