Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | AOC1 | P19801 | 4/20 | 0.57 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.55 |
| ▸ | BRS3 | P32247 | 1/20 | 0.46 |
| ▸ | LATS1 | O95835 | 1/20 | 0.46 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19851080 | 1.00 | KDM4E (0.59) | KDM4EGAAMAPTAOC1AOC3 | |
| SCHEMBL16054255 | 1.00 | KDM4E (0.59) | KDM4EGAAMAPTAOC1AOC3 | |
| SCHEMBL5958407 | 0.91 | AOC1 (0.54) | KDM4EGAAMAPTAOC1AOC3 | |
| SCHEMBL29539060 | 0.91 | AOC1 (0.54) | KDM4EGAAMAPTAOC1AOC3 | |
| SCHEMBL28577780 | 0.86 | AOC1 (0.61) | KDM4EGAAMAPTAOC1AOC3 | |
| SCHEMBL28564192 | 0.84 | AOC1 (0.62) | KDM4EGAAMAPTAOC1AOC3 | |
| SCHEMBL16695821 | 0.83 | MAPK1 (0.45) | KDM4EGAAMAPTAOC1AOC3 | |
| SCHEMBL15651849 | 0.83 | AOC1 (0.48) | KDM4EGAAMAPTAOC1AOC3 | |
| SCHEMBL14046305 | 0.83 | ROCK2 (0.50) | KDM4EGAAMAPTAOC1AOC3 | |
| SCHEMBL19980620 | 0.82 | PRKCZ (0.61) | HIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10399978-B2 | Imidazopyridine thioglycolic acid derivatives as potent inhibitors of human urate transporter 1 | SHANDONG UNIVERSITY (CN) | 2019-09-03 | — | — | US | disclosed |
| US-20190225606-A1 | Novel Imidazopyridine Thioglycolic Acid Derivatives as Potent Inhibitors of Human Urate Transporter 1 | SHANDONG UNIVERSITY (CN) | 2019-07-25 | — | — | US | disclosed |
| EP-3495362-A1 | IMIDAZOPYRIDINE THIOGLYCOLIC ACID DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Shandong University (CN) | 2019-06-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190225606-A1 | Novel Imidazopyridine Thioglycolic Acid Derivatives as Potent Inhibitors of Human Urate Transporter 1 | SLC29A1, SLC28A1, SLC5A1 | KDM4E 4243/4885GAA 375/4885MAPT 2058/4885 |
| US-10399978-B2 | Imidazopyridine thioglycolic acid derivatives as potent inhibitors of human urate transporter 1 | SLC29A1, SLC28A1, SLC5A1 | KDM4E 4231/4885GAA 371/4885MAPT 1810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.