SCHEMBL21094385

SCHEMBL21094385

CCC(CC)(C(=O)OCc1ccccc1)[C@H]1CC[C@@H](c2cccc(F)c2)N1

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PKM P14618 1/20 0.47
KCNH2 Q12809 7/20 0.43
ALDH1A1 P00352 3/20 0.38
SCN3A Q9NY46 3/20 0.38
LMNA P02545 1/20 0.38
HCAR2 Q8TDS4 1/20 0.36
TSHR P16473 1/20 0.36
PDE1C Q14123 1/20 0.35
MEN1 O00255 1/20 0.35
HCRTR1 O43613 1/20 0.35
KMT2A Q03164 1/20 0.35
GPR55 Q9Y2T6 1/20 0.35
KDM4E B2RXH2 1/20 0.35
GAA P10253 1/20 0.35
STAT1 P42224 1/20 0.35
RAB9A P51151 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21094400 0.90 KCNH2 (0.44) KCNH2ALDH1A1SCN3ATSHRPDE1C
SCHEMBL21094403 0.89 ALDH1A1 (0.45) PKMKCNH2ALDH1A1SCN3ALMNA
SCHEMBL21093967 0.87 PKM (0.37) PKMKCNH2TSHRMEN1KMT2A
SCHEMBL21093976 0.87 TSHR (0.38) PKMKCNH2TSHR
SCHEMBL21094391 0.81 KCNH2 (0.42) KCNH2ALDH1A1SCN3A
SCHEMBL21094390 0.79 ALDH1A1 (0.38) KCNH2ALDH1A1SCN3A
SCHEMBL21094396 0.79 RIPK1 (0.39) KCNH2ALDH1A1SCN3A
SCHEMBL21094399 0.78 KCNH2 (0.38) KCNH2ALDH1A1SCN3A
SCHEMBL21094100 0.77 SSTR4 (0.39) KCNH2ALDH1A1SCN3AMEN1KMT2A
SCHEMBL20835402 0.77 ALDH1A1 (0.45) PKMKCNH2ALDH1A1SCN3ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019112024-A1 PYRROLIDINE COMPOUND キッセイ薬品工業株式会社 2019-06-13 WO disclosed