⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21391723 | 0.84 | — | — | |
| SCHEMBL21417287 | 0.65 | — | — | |
| SCHEMBL24705186 | 0.65 | — | — | |
| SCHEMBL3390481 | 0.65 | — | — | |
| SCHEMBL28204440 | 0.65 | LMNA (0.32) | — | |
| SCHEMBL11356129 | 0.59 | — | — | |
| SCHEMBL4961193 | 0.58 | LMNA (0.35) | — | |
| SCHEMBL2116267 | 0.56 | CCR5 (0.33) | — | |
| SCHEMBL20960942 | 0.55 | ALDH1A1 (0.41) | — | |
| SCHEMBL1404045 | 0.55 | HSD11B1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023239892-A1 | COMPOUNDS FOR MODULATION OF CD68 AND USES THEREOF | ARKUDA THERAPEUTICS (US) | 2023-12-14 | — | — | WO | disclosed |
| EP-3724188-B1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2023-06-07 | — | — | EP | disclosed |
| WO-2019118528-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2019-06-20 | — | — | WO | disclosed |