Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330432 | 0.81 | CHRM1 (0.42) | CHRM1CHRM2CHRM4CHRM3ALDH1A1 | |
| SCHEMBL3319442 | 0.74 | CHRM2 (0.42) | CHRM1CHRM2ALDH1A1MAPT | |
| SCHEMBL9400768 | 0.74 | CHRM1 (0.42) | CHRM1ALDH1A1MAPT | |
| SCHEMBL9400765 | 0.74 | CHRM1 (0.42) | CHRM1ALDH1A1MAPT | |
| SCHEMBL9696817 | 0.72 | ALDH1A1 (0.46) | CHRM1CHRM2CHRM4CHRM3ALDH1A1 | |
| SCHEMBL9696811 | 0.72 | CHRM1 (0.40) | CHRM1CHRM2GAACHRNB2CHRNA4 | |
| SCHEMBL25606145 | 0.72 | CHRM1 (0.40) | CHRM1CHRM2GAACHRNB2CHRNA4 | |
| SCHEMBL9523751 | 0.72 | CHRM2 (0.41) | CHRM1CHRM2CHRM4CHRM3ALDH1A1 | |
| SCHEMBL4339192 | 0.70 | CHRM2 (0.42) | CHRM1CHRM2CHRM4CHRM3ALDH1A1 | |
| SCHEMBL7493133 | 0.70 | CHRM2 (0.42) | CHRM1CHRM2CHRM4CHRM3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019118528-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2019-06-20 | — | — | WO | disclosed |