Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9400765 | 1.00 | CHRM1 (0.42) | CHRM1MAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL10570225 | 0.91 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL7330432 | 0.89 | CHRM1 (0.42) | CHRM1MAPTALDH1A1 | |
| SCHEMBL9696817 | 0.83 | ALDH1A1 (0.46) | CHRM1MAPTALDH1A1 | |
| SCHEMBL3319442 | 0.82 | CHRM2 (0.42) | CHRM1MAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL9698264 | 0.76 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1 | |
| SCHEMBL3317652 | 0.75 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL8552623 | 0.74 | CHRM1 (0.42) | CHRM1ALDH1A1 | |
| SCHEMBL21095888 | 0.74 | CHRM1 (0.38) | CHRM1MAPTALDH1A1 | |
| SCHEMBL9696811 | 0.73 | CHRM1 (0.40) | CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5362739-A | Acetylcholine activators, dementia treatment | BEECHAM GROUP P.L.C. (GB) | 1994-11-08 | — | — | US | disclosed |
| EP-0544773-A1 | AZABICYCLIC COMPOUNDS, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992003435-A1 | AZABICYCLIC COMPOUNDS, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1992-03-05 | — | — | WO | disclosed |