Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25606145 | 1.00 | CHRM1 (0.40) | CHRM1CHRNB2CHRNA4POLBCHRM2 | |
| SCHEMBL7319174 | 0.92 | CHRM2 (0.41) | CHRM1CHRNB2CHRNA4POLBCHRM2 | |
| SCHEMBL23315373 | 0.92 | CHRM2 (0.41) | CHRM1CHRNB2CHRNA4POLBCHRM2 | |
| SCHEMBL23435952 | 0.92 | CHRM2 (0.41) | CHRM1CHRNB2CHRNA4POLBCHRM2 | |
| SCHEMBL9697942 | 0.83 | CHRM1 (0.45) | CHRM1CHRNB2CHRNA4CHRM2KMT2A | |
| SCHEMBL7328671 | 0.76 | ALDH1A1 (0.40) | CHRM1CHRNB2CHRNA4POLBCHRM2 | |
| SCHEMBL21095889 | 0.75 | SLC6A12 (0.39) | CHRM1CHRNB2CHRNA4CHRM2KMT2A | |
| SCHEMBL21095754 | 0.75 | SLC6A12 (0.39) | CHRM1CHRNB2CHRNA4CHRM2KMT2A | |
| SCHEMBL9698254 | 0.75 | CHRM1 (0.38) | CHRM1CHRNB2CHRNA4CHRM2KMT2A | |
| SCHEMBL12614403 | 0.75 | CHRM2 (0.43) | CHRM1CHRM2KMT2AMEN1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724188-B1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2023-06-07 | — | — | EP | disclosed |
| WO-2019118528-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2019-06-20 | — | — | WO | disclosed |
| US-5091397-A | Cognition activators | BEECHAM GROUP P.L.C. (GB) | 1992-02-25 | — | — | US | disclosed |
| EP-0363085-A2 | Novel compounds | BEECHAM GROUP PLC (GB) | 1990-04-11 | — | — | EP | disclosed |