Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 12/20 | 0.33 |
| ▸ | JAK2 | O60674 | 11/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | LYN | P07948 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | ROS1 | P08922 | 1/20 | 0.32 |
| ▸ | FGR | P09769 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | TIE1 | P35590 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21097345 | 1.00 | ALDH1A1 (0.36) | ALDH1A1KDM4EHDAC6HDAC8NTRK1 | |
| SCHEMBL21097304 | 0.88 | NTRK1 (0.41) | NTRK1JAK2 | |
| SCHEMBL21097303 | 0.88 | NTRK1 (0.41) | NTRK1JAK2 | |
| SCHEMBL21097344 | 0.82 | NTRK1 (0.38) | ALDH1A1NTRK1JAK2INSRLYN | |
| SCHEMBL21097346 | 0.82 | NTRK1 (0.38) | ALDH1A1NTRK1JAK2INSRLYN | |
| SCHEMBL21097309 | 0.81 | TRPA1 (0.48) | KDM4ETRPA1HTT | |
| SCHEMBL21097310 | 0.81 | TRPA1 (0.48) | KDM4ETRPA1HTT | |
| SCHEMBL15039643 | 0.73 | NTRK1 (0.41) | NTRK1JAK2 | |
| SCHEMBL16292809 | 0.73 | NTRK1 (0.41) | NTRK1JAK2 | |
| SCHEMBL21097302 | 0.72 | GRIA4 (0.36) | NTRK1JAK2TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10344031-B2 | Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2019-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10344031-B2 | Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors | MUSK, DMPK, PNCK | ALDH1A1 3267/4885KDM4E 2770/4885HDAC6 1195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.