Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 2/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24691341 | 0.81 | HPGD (0.51) | SMN1; SMN2ALDH1A1MEN1NPC1KMT2A | |
| SCHEMBL19629770 | 0.81 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1NR1H4HDAC1MEN1 | |
| SCHEMBL20048953 | 0.80 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1NR1H4HDAC1NPC1 | |
| SCHEMBL24325340 | 0.76 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1NR1H4HDAC1MEN1 | |
| SCHEMBL30984365 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1NR1H4HDAC1MEN1 | |
| SCHEMBL19345855 | 0.75 | KMT2A (0.44) | SMN1; SMN2ALDH1A1MEN1NPC1KMT2A | |
| SCHEMBL17149422 | 0.75 | SMN1; SMN2 (0.62) | SMN1; SMN2NR1H4MEN1NPC1KMT2A | |
| SCHEMBL12377330 | 0.72 | NR1H4 (0.63) | ALDH1A1NR1H4HDAC1MEN1NPC1 | |
| SCHEMBL19627369 | 0.70 | NLRP3 (0.53) | ALDH1A1MEN1KMT2AEPHX2MAPT | |
| SCHEMBL19632078 | 0.69 | LMNA (0.44) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019118571-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2019-06-20 | — | — | WO | disclosed |