Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | OGG1 | O15527 | 1/20 | 0.38 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.38 |
| ▸ | CHRNG | P07510 | 1/20 | 0.38 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.38 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2298661 | 0.85 | MEN1 (0.48) | LMNAALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL10679757 | 0.79 | MEN1 (0.42) | LMNAALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL27301554 | 0.76 | PARP1 (0.47) | LMNAALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL24691341 | 0.72 | HPGD (0.51) | LMNAHPGDALDH1A1MEN1KMT2A | |
| Benzene SCHEMBL11580699 | 0.72 | MEN1 (0.69) | LMNAHPGDALDH1A1MEN1MAPT | |
| SCHEMBL5448808 | 0.69 | HPGD (0.70) | LMNAHPGDMEN1KMT2ASLC6A2 | |
| SCHEMBL21098149 | 0.69 | SMN1; SMN2 (0.42) | LMNAALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL19627379 | 0.69 | FBP1 (0.63) | — | |
| SCHEMBL28982445 | 0.68 | IDO1 (0.40) | ALDH1A1MEN1MAPTKMT2ACYP2C19 | |
| SCHEMBL1224992 | 0.68 | TRPM5 (0.54) | HPGDALDH1A1MEN1KMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017201155-A1 | lSOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2017-11-23 | — | — | WO | disclosed |