Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | MMP9 | P14780 | 5/20 | 0.49 |
| ▸ | MMP2 | P08253 | 4/20 | 0.49 |
| ▸ | MMP14 | P50281 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2111285 | 0.79 | EGLN1 (0.46) | NPC1RAB9AMMP2ALDH1A1SMN1; SMN2 | |
| SCHEMBL2111462 | 0.78 | L3MBTL1 (0.53) | ALOX12NPC1RAB9AMMP9MMP2 | |
| SCHEMBL2109762 | 0.77 | ALDH1A1 (0.61) | ALOX12NPC1RAB9AMMP9MMP2 | |
| SCHEMBL2111796 | 0.76 | NPC1 (0.54) | ALOX12NPC1RAB9AMMP9MMP2 | |
| SCHEMBL2110205 | 0.76 | TAS1R3 (0.58) | ALOX12NPC1RAB9AMMP9MMP14 | |
| SCHEMBL14776032 | 0.76 | TAS1R3 (0.58) | ALOX12NPC1RAB9AMMP9MMP14 | |
| SCHEMBL2108506 | 0.75 | KDM4E (0.47) | ALOX12NPC1RAB9AMMP9MMP2 | |
| SCHEMBL30685737 | 0.75 | TDP1 (0.63) | MEN1ALDH1A1LMNATP53MAPT | |
| SCHEMBL14775771 | 0.74 | L3MBTL1 (0.59) | ALOX12NPC1RAB9AMMP9MMP2 | |
| SCHEMBL28411600 | 0.73 | CKS1B (0.55) | NPC1RAB9AMEN1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963272-B1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-03-20 | — | — | EP | claimed |
| US-8158799-B2 | Hydroxyquinoline derivatives | Merck Patent Gesellschaft MIT Meschraenkter Haftung (DE) | 2012-04-17 | — | — | US | claimed |
| EP-1963272-B1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-03-20 | — | — | EP | disclosed |
| EP-1963272-B1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-03-20 | — | — | EP | disclosed |
| US-8158799-B2 | Hydroxyquinoline derivatives | Merck Patent Gesellschaft MIT Meschraenkter Haftung (DE) | 2012-04-17 | — | — | US | disclosed |
| US-8158799-B2 | Hydroxyquinoline derivatives | Merck Patent Gesellschaft MIT Meschraenkter Haftung (DE) | 2012-04-17 | — | — | US | disclosed |
| US-20080312278-A1 | Hydroxyquinoline Derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2008-12-18 | — | — | US | disclosed |
| US-20080312278-A1 | Hydroxyquinoline Derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2008-12-18 | — | — | US | disclosed |
| WO-2007068316-A1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312278-A1 | Hydroxyquinoline Derivatives | MKI67, CCNT1, CCNY | ALOX12 2349/4885NPC1 1502/4885RAB9A 2373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.