Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 10/20 | 0.56 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.47 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 6/20 | 0.46 |
| ▸ | IGF1R | P08069 | 5/20 | 0.46 |
| ▸ | TTK | P33981 | 3/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | FES | P07332 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21099605 | 0.95 | ALK (0.62) | ALKINSRIGF1RTTKFES | |
| SCHEMBL21099489 | 0.92 | ALK (0.54) | ALKDCLK1MAPK7LRRK2INSR | |
| SCHEMBL21100193 | 0.87 | IRAK4 (0.59) | ALKLRRK2PLK1IRAK4EGFR | |
| SCHEMBL21099658 | 0.86 | ALK (0.60) | ALKDCLK1MAPK7LRRK2INSR | |
| SCHEMBL21099498 | 0.86 | ALK (0.60) | ALKDCLK1MAPK7LRRK2INSR | |
| SCHEMBL21099499 | 0.86 | ALK (0.75) | ALKINSRIGF1RPLK1EGFR | |
| SCHEMBL21099660 | 0.85 | ALK (0.76) | ALKDCLK1MAPK7LRRK2INSR | |
| SCHEMBL21099502 | 0.85 | ALK (0.59) | ALKDCLK1LRRK2INSRIGF1R | |
| SCHEMBL21099810 | 0.84 | IRAK4 (0.46) | ALKTTKPLK1IRAK4EGFR | |
| SCHEMBL21099501 | 0.83 | ALK (0.52) | ALKINSRIGF1REGFRPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3498716-A1 | THIENOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS | Hongyun Biotech Co., Ltd. (CN) | 2019-06-19 | — | — | EP | disclosed |