Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.66 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.54 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.53 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.53 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.53 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.53 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.51 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10045072 | 0.95 | SMN1; SMN2 (0.65) | SMN1; SMN2HRH4HRH3LMNACYP1A2 | |
| SCHEMBL10045173 | 0.87 | L3MBTL1 (0.62) | SMN1; SMN2HRH4HRH3LMNACYP1A2 | |
| SCHEMBL10045171 | 0.87 | L3MBTL1 (0.62) | SMN1; SMN2HRH4HRH3LMNACYP1A2 | |
| SCHEMBL9259496 | 0.87 | HRH4 (0.84) | SMN1; SMN2HRH4HRH3LMNACYP1A2 | |
| SCHEMBL10748421 | 0.87 | HRH4 (0.84) | SMN1; SMN2HRH4HRH3LMNACYP1A2 | |
| SCHEMBL9637156 | 0.87 | HRH4 (0.84) | SMN1; SMN2HRH4HRH3LMNACYP1A2 | |
| SCHEMBL10747074 | 0.87 | HRH4 (0.84) | SMN1; SMN2HRH4HRH3LMNACYP1A2 | |
| SCHEMBL10045143 | 0.85 | L3MBTL1 (0.64) | SMN1; SMN2HRH4HRH3CYP1A2CYP2D6 | |
| SCHEMBL11922726 | 0.85 | L3MBTL1 (0.64) | SMN1; SMN2HRH4HRH3LMNACYP1A2 | |
| SCHEMBL10045180 | 0.85 | L3MBTL1 (0.55) | SMN1; SMN2HRH4HRH3LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10329257-B2 | Compositions and methods for treating tuberculosis | THE BROAD INSTITUTE, INC. (US) | 2019-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10329257-B2 | Compositions and methods for treating tuberculosis | C5, IFNG, TERT | SMN1; SMN2 4633/4885HRH4 1456/4885HRH3 2194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.