Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 4/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12226954 | 0.84 | TRPA1 (0.42) | BACE1KDM4EALDH1A1ALOX5GAA | |
| SCHEMBL11312772 | 0.84 | BACE1 (0.46) | BACE1KDM4EALDH1A1ALOX5GAA | |
| SCHEMBL8750442 | 0.83 | EGFR (0.41) | BACE1ALOX5CYP4F2CYP4A11CA2 | |
| SCHEMBL2399831 | 0.83 | CYP4F2 (0.41) | BACE1KDM4EALDH1A1ALOX5GAA | |
| SCHEMBL4279450 | 0.81 | TRPA1 (0.44) | ALDH1A1ALOX5MAPTCA2SKP2 | |
| SCHEMBL18571056 | 0.80 | BACE1 (0.59) | BACE1KDM4EALDH1A1MAPTSKP2 | |
| SCHEMBL19314032 | 0.80 | SKP2 (0.61) | KDM4EALDH1A1MAPTCA2SKP2 | |
| SCHEMBL6301819 | 0.79 | ALDH1A1 (0.52) | BACE1KDM4EALDH1A1ALOX5GAA | |
| SCHEMBL23954004 | 0.77 | HRH3 (0.48) | ALDH1A1MAPT | |
| SCHEMBL18570898 | 0.77 | SKP2 (0.49) | BACE1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10745356-B2 | Compositions and methods for treating tuberculosis | THE BROAD INSTITUTE, INC. (US) | 2020-08-18 | — | — | US | disclosed |
| US-20190284140-A1 | COMPOSITIONS AND METHODS FOR TREATING TUBERCULOSIS | THE BROAD INSTITUTE, INC. | 2019-09-19 | — | — | US | disclosed |
| US-10329257-B2 | Compositions and methods for treating tuberculosis | THE BROAD INSTITUTE, INC. (US) | 2019-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10745356-B2 | Compositions and methods for treating tuberculosis | C5, IFNG, TERT | BACE1 1506/4885KDM4E 3217/4885ALDH1A1 1848/4885 |
| US-10329257-B2 | Compositions and methods for treating tuberculosis | C5, IFNG, TERT | BACE1 1506/4885KDM4E 3217/4885ALDH1A1 1848/4885 |
| US-20190284140-A1 | COMPOSITIONS AND METHODS FOR TREATING TUBERCULOSIS | C5, IFNG, TERT | BACE1 1506/4885KDM4E 3217/4885ALDH1A1 1848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.