Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | KDM1A | O60341 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21101005 | 0.88 | KDM1A (0.50) | SIGMAR1KDM1ADRD2MAOBHTR2A | |
| SCHEMBL12821564 | 0.83 | KDM1A (0.73) | KDM1ADRD2MAOBHTR2ASLC6A4 | |
| SCHEMBL12821566 | 0.83 | KDM1A (0.73) | KDM1ADRD2MAOBHTR2ASLC6A4 | |
| SCHEMBL12966211 | 0.83 | SIGMAR1 (0.48) | SIGMAR1DRD2CHRM4ALDH1A1CCR3 | |
| SCHEMBL19725557 | 0.81 | KDM1A (0.67) | KDM1ADRD2MAOBHTR2ASLC6A4 | |
| SCHEMBL21101194 | 0.80 | MCHR1 (0.56) | SIGMAR1KDM1ADRD2MAOBHTR2A | |
| SCHEMBL21101342 | 0.80 | CYP2D6 (0.60) | SIGMAR1KDM1ADRD2MAOBHTR2A | |
| SCHEMBL21101256 | 0.79 | SIGMAR1 (0.52) | SIGMAR1KDM1ADRD2MAOBHTR2A | |
| SCHEMBL21101096 | 0.78 | BCHE (0.62) | SIGMAR1DRD2SLC6A4CXCR3ACHE | |
| SCHEMBL21100977 | 0.77 | ALDH1A1 (0.52) | SIGMAR1KDM1ADRD2MAOBHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2688568-B1 | CYCLOPROPYLAMINES AS LSD1 INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2019-06-19 | — | — | EP | disclosed |