Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CTSD | P07339 | 2/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.41 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21101905 | 0.88 | ALPL (0.46) | BRD4LMNAALPLALPIPOLB | |
| SCHEMBL21101911 | 0.87 | KDM4E (0.43) | BRD4LMNAALPLALPIPOLB | |
| SCHEMBL21101771 | 0.86 | POLB (0.55) | POLBCA1CA2CTSDHTT | |
| SCHEMBL21102114 | 0.85 | LMNA (0.52) | LMNAPOLBALDH1A1CTSDMEN1 | |
| SCHEMBL21101904 | 0.84 | ALDH1A1 (0.60) | LMNAPOLBALDH1A1MAPTKMT2A | |
| SCHEMBL21102111 | 0.82 | LMNA (0.59) | LMNAALDH1A1CTSDMEN1MAPT | |
| SCHEMBL21101766 | 0.81 | BRD4 (0.55) | BRD4LMNAPOLBCA1CA2 | |
| SCHEMBL21101906 | 0.78 | KDM4E (0.66) | ALDH1A1HTTMEN1MAPTKMT2A | |
| SCHEMBL21101769 | 0.78 | NPC1 (0.46) | POLBALDH1A1BACE1HTTMEN1 | |
| SCHEMBL21101777 | 0.74 | LMNA (0.53) | BRD4LMNAPOLBCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019111225-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF NON‑ALCOHOLIC STEATOHEPATITIS | AVALIV THERAPEUTICS (US) | 2019-06-13 | — | — | WO | disclosed |