Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 3/20 | 0.39 |
| ▸ | RXRB | P28702 | 3/20 | 0.39 |
| ▸ | RXRG | P48443 | 3/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | GRB2 | P62993 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ESRRB | O95718 | 1/20 | 0.37 |
| ▸ | ESRRG | P62508 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL265118 | 0.86 | PIK3CA (0.53) | POLBPIK3CAHDAC1HDAC8RXRA | |
| SCHEMBL4689867 | 0.83 | NR1H4 (0.51) | POLBHDAC8RXRARXRBRXRG | |
| SCHEMBL26382764 | 0.82 | POLB (0.44) | POLBCYP2C19GRIA2PIK3CAHDAC1 | |
| SCHEMBL2652603 | 0.81 | RXRA (0.56) | PIK3CAHDAC1HDAC8RXRARXRB | |
| SCHEMBL8403545 | 0.80 | POLB (0.61) | POLBCES1LMNA | |
| SCHEMBL21101918 | 0.80 | TACR1 (0.37) | POLBCYP2C19GRIA2RXRARXRB | |
| SCHEMBL9271085 | 0.78 | CNR2 (0.48) | POLBCYP2C19MAPTSMN1; SMN2 | |
| SCHEMBL21101909 | 0.78 | CYP1A2 (0.50) | CYP2C19HDAC1HDAC8MAOBMAPT | |
| SCHEMBL26382771 | 0.78 | POLB (0.49) | POLBCYP2C19GRIA2PIK3CAHDAC1 | |
| SCHEMBL9266226 | 0.77 | LTA4H (0.56) | POLBPIK3CAHDAC1HDAC8EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019111225-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF NON‑ALCOHOLIC STEATOHEPATITIS | AVALIV THERAPEUTICS (US) | 2019-06-13 | — | — | WO | disclosed |