Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 4/20 | 0.37 |
| ▸ | RXRA | P19793 | 3/20 | 0.35 |
| ▸ | RXRB | P28702 | 3/20 | 0.35 |
| ▸ | RXRG | P48443 | 3/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21101912 | 0.94 | TACR1 (0.35) | TACR1RXRARXRBRXRGIDO1 | |
| SCHEMBL21101913 | 0.88 | MEN1 (0.34) | TACR1CYP2C19CYP1A2CYP2D6CYP3A4 | |
| SCHEMBL6492340 | 0.86 | IDO1 (0.48) | TACR1RXRARXRBRXRGIDO1 | |
| SCHEMBL4286759 | 0.83 | RXRA (0.49) | RXRARXRBRXRGPOLBCYP2C19 | |
| SCHEMBL21101909 | 0.82 | CYP1A2 (0.50) | IDO1CYP2C19CYP1A2 | |
| SCHEMBL21101910 | 0.80 | POLB (0.46) | RXRARXRBRXRGPOLBCYP2C19 | |
| SCHEMBL12301741 | 0.76 | TACR1 (0.40) | TACR1RXRARXRBRXRGIDO1 | |
| SCHEMBL7356993 | 0.76 | RXRA (0.49) | TACR1RXRARXRBRXRGIDO1 | |
| SCHEMBL21101915 | 0.74 | TACR1 (0.36) | TACR1CYP2C19CYP1A2CYP2D6PSEN1 | |
| SCHEMBL21101768 | 0.74 | RXRA (0.44) | RXRARXRBRXRGPOLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019111225-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF NON‑ALCOHOLIC STEATOHEPATITIS | AVALIV THERAPEUTICS (US) | 2019-06-13 | — | — | WO | disclosed |