Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10744953 | 0.83 | ALDH1A1 (0.56) | KDM4EALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL5742233 | 0.80 | KDM4E (0.60) | KDM4EALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL4320604 | 0.80 | KDM4E (0.60) | KDM4EALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL17993523 | 0.80 | ALDH1A1 (0.54) | KDM4EALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL2605820 | 0.79 | KMT2A (0.56) | KDM4EALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL2307800 | 0.78 | PTGS2 (0.55) | KDM4EALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL14543978 | 0.78 | SMN1; SMN2 (0.59) | KDM4EALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL7131019 | 0.76 | KMT2A (0.58) | KDM4EALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL4683243 | 0.76 | KDM4E (0.55) | KDM4EALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL7046945 | 0.76 | PTGS2 (0.57) | KDM4EALDH1A1LMNAGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019111225-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF NON‑ALCOHOLIC STEATOHEPATITIS | AVALIV THERAPEUTICS (US) | 2019-06-13 | — | — | WO | disclosed |