Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 16/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 16/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1923 | 0.87 | CTSL (0.37) | SLC6A4SLC6A3SLC6A2OPRK1ALDH1A1 | |
| SCHEMBL2793 | 0.85 | SLC6A4 (0.57) | SLC6A4SLC6A3SLC6A2KCNH2 | |
| SCHEMBL9863819 | 0.84 | SLC6A4 (0.47) | SLC6A4SLC6A3SLC6A2CYP3A4ALOX15 | |
| SCHEMBL2644 | 0.83 | CYP3A4 (0.58) | SLC6A4SLC6A3SLC6A2CYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL2434 | 0.83 | SLC6A4 (0.54) | SLC6A4SLC6A3SLC6A2CYP3A4ALOX15 | |
| SCHEMBL2190 | 0.82 | SLC6A3 (0.46) | SLC6A4SLC6A3SLC6A2 | |
| Hydrochloric Acid SCHEMBL1902 | 0.75 | SLC6A4 (0.51) | SLC6A4SLC6A3SLC6A2CYP3A4ALOX15 | |
| SCHEMBL10550753 | 0.75 | SLC6A4 (0.71) | SLC6A4SLC6A3SLC6A2CYP3A4ALOX15 | |
| SCHEMBL9116253 | 0.75 | HDAC4 (0.36) | SLC6A4SLC6A3HDAC4 | |
| Hydrochloric Acid SCHEMBL10840401 | 0.74 | SLC6A4 (0.42) | SLC6A4SLC6A3SLC6A2CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4814352-A | ANTIDEPRESSANT CYCLOBUTYL BENZYLAMINE | THE BOOTS COMPANY PLC (GB) | 1989-03-21 | — | — | US | disclosed |
| US-4806570-A | ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1989-02-21 | — | — | US | disclosed |
| US-4767790-A | ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1988-08-30 | — | — | US | disclosed |
| US-4746680-A | ANTIDEPRESSANTS | THE BOOTS COMPANY P.L.C. (GB) | 1988-05-24 | — | — | US | disclosed |
| US-4522828-A | CYCLOBUTYLALKYLAMINE COMPOUNDS, ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1985-06-11 | — | — | US | disclosed |