Metbufen

Metbufen

SCHEMBL2111106

CC(CC(=O)c1ccc(-c2ccccc2)cc1)C(=O)O

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.59
MAPT P10636 5/20 0.59
L3MBTL1 Q9Y468 3/20 0.59
HPGD P15428 2/20 0.56
PTPN1 P18031 1/20 0.55
GSK3B P49841 1/20 0.55
ALDH1A1 P00352 4/20 0.54
KDM4E B2RXH2 2/20 0.54
USP2 O75604 1/20 0.54
LMNA P02545 2/20 0.54
RAB9A P51151 2/20 0.53
FFAR1 O14842 1/20 0.53
CYP1A2 P05177 1/20 0.53
HIF1A Q16665 1/20 0.53
TSHR P16473 1/20 0.52
ERCC5 P28715 1/20 0.51
FEN1 P39748 1/20 0.51
HAO1 Q9UJM8 1/20 0.51
AGTR1 P30556 1/20 0.51
NPC1 O15118 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL135355 0.89 L3MBTL1 (0.66) SMN1; SMN2MAPTL3MBTL1HPGDPTPN1
SCHEMBL2739301 0.85 MAPT (0.63) SMN1; SMN2MAPTL3MBTL1HPGDPTPN1
SCHEMBL4559589 0.84 SMN1; SMN2 (0.61) SMN1; SMN2MAPTL3MBTL1HPGDPTPN1
SCHEMBL8537118 0.83 PTPN1 (0.66) SMN1; SMN2MAPTL3MBTL1HPGDPTPN1
SCHEMBL11763415 0.82 SMN1; SMN2 (0.59) SMN1; SMN2MAPTL3MBTL1HPGDPTPN1
SCHEMBL8775647 0.81 ALDH1A1 (0.58) SMN1; SMN2MAPTL3MBTL1HPGDGSK3B
SCHEMBL27497371 0.81 MMP2 (0.51) SMN1; SMN2MAPTL3MBTL1HPGDALDH1A1
SCHEMBL11530697 0.81 MAPT (0.62) SMN1; SMN2MAPTL3MBTL1HPGDPTPN1
SCHEMBL11871072 0.81 SMN1; SMN2 (0.58) SMN1; SMN2MAPTL3MBTL1HPGDPTPN1
SCHEMBL11161484 0.80 KMT2A (0.57) SMN1; SMN2MAPTL3MBTL1HPGDGSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
US-20220047505-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2022-02-17 US disclosed
US-11191719-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2021-12-07 US disclosed
US-10463611-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2019-11-05 US disclosed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US disclosed
US-20140154313-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2014-06-05 US disclosed
EP-2717860-A1 CONTROLLED ABSORPTION WATER-SOLUBLE PHARMACEUTICALLY ACTIVE ORGANIC COMPOUND FORMULATION FOR ONCE-DAILY ADMINISTRATION STI Pharma, LLC (US) 2014-04-16 EP disclosed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP disclosed
US-20020102215-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2002-08-01 US disclosed
US-20020102217-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2002-08-01 US disclosed
US-6331289-B1 ULTRASOUND CONTRAST AGENTS, SUSPENSION IN AQUEOUS CARRIER LIQUID OF A REPORTER COMPRISING GAS-CONTAINING OR GAS-GENERATING MATERIAL, AGENT CAPABLE OF FORMING AT LEAST TWO TYPES OF BINDING PAIRS WITH TARGET; REPORTER BEING CONJUGATED NYCOMED IMAGING AS (NO) 2001-12-18 US disclosed
US-6264917-B1 MIXTURE OF GAS FILLED MICROBUBBLES AND RELEASING AGENT NYCOMED IMAGING AS (NO) 2001-07-24 US disclosed
US-6261537-B1 TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES NYCOMED IMAGING AS (NO) 2001-07-17 US disclosed
US-4683331-A ANTIINFLAMMATORY SPOFA SPOJENE PODNIKY PRO ZDRAVOTNICKOU (CS) 1987-07-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020102215-A1 Diagnostic/therapeutic agents BID, FUS, FABP1 SMN1; SMN2 1978/4885MAPT 2239/4885L3MBTL1 750/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.