Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 15/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21111150 | 1.00 | USP30 (0.42) | USP30RIPK1DRD2DRD3KMT2A | |
| SCHEMBL21111282 | 0.85 | RIPK1 (0.41) | USP30RIPK1 | |
| SCHEMBL21111285 | 0.85 | RIPK1 (0.41) | USP30RIPK1 | |
| SCHEMBL19980292 | 0.82 | USP30 (0.47) | USP30RIPK1DRD2DRD3KMT2A | |
| SCHEMBL18409596 | 0.80 | RIPK1 (0.41) | RIPK1 | |
| SCHEMBL18409597 | 0.80 | RIPK1 (0.41) | RIPK1 | |
| SCHEMBL15964689 | 0.79 | RIPK1 (0.43) | USP30RIPK1 | |
| SCHEMBL17312486 | 0.78 | RIPK1 (0.41) | RIPK1 | |
| SCHEMBL17312488 | 0.78 | RIPK1 (0.41) | RIPK1 | |
| SCHEMBL17312429 | 0.76 | KIF11 (0.40) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3508484-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2019-07-10 | — | — | EP | disclosed |