Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 3/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 2/20 | 0.38 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18002539 | 0.84 | PSEN1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1250518 | 0.83 | LMNA (0.53) | MAPTLMNACYP2C9HPGDCYP2C19 | |
| SCHEMBL21111524 | 0.82 | PSEN1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL30087228 | 0.82 | PSEN1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14455033 | 0.82 | PSEN1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL558160 | 0.80 | POLB (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5914742 | 0.80 | MAPT (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22588321 | 0.79 | MCL1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4416927 | 0.78 | MCL1 (0.50) | LMNAHPGDCYP2C19KMT2AMCL1 | |
| SCHEMBL1251479 | 0.77 | STING1 (0.33) | ACLYMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240425437-A1 | DERIVATIVES OF SOBETIROME | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2024-12-26 | — | — | US | disclosed |
| US-11578032-B2 | Derivatives of sobetirome | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2023-02-14 | — | — | US | disclosed |
| US-11578032-B2 | Derivatives of sobetirome | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2023-02-14 | — | — | US | disclosed |
| EP-3936497-A1 | PROCESS FOR THE PREPARATION OF DERIVATIVES OF SOBETIROME | Oregon Health & Science University (US) | 2022-01-12 | — | — | EP | disclosed |
| CN-113277958-A | Subtiprotero derivatives | 俄勒冈健康科学大学 | 2021-08-20 | — | — | CN | disclosed |
| CN-109475121-B | Subtiprotero derivatives | 俄勒冈健康科学大学 | 2021-06-25 | — | — | CN | disclosed |
| EP-3457851-B1 | DERIVATIVES OF SOBETIROME | UNIV OREGON HEALTH & SCIENCE (US) | 2021-06-23 | — | — | EP | disclosed |
| US-20210002208-A1 | DERIVATIVES OF SOBETIROME | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2021-01-07 | — | — | US | disclosed |
| US-20210002208-A1 | DERIVATIVES OF SOBETIROME | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2021-01-07 | — | — | US | disclosed |
| EP-3752001-A1 | DERIVATIVES OF SOBETIROME | Oregon Health & Science University (US) | 2020-12-23 | — | — | EP | disclosed |
| CN-111818798-A | Derivatives of Sobutirole | 俄勒冈健康科学大学 | 2020-10-23 | — | — | CN | disclosed |
| US-20200325092-A1 | DERIVATIVES OF SOBETIROME | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2020-10-15 | — | — | US | disclosed |
| US-10544075-B2 | Derivatives of sobetirome | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2020-01-28 | — | — | US | disclosed |
| WO-2019160980-A1 | DERIVATIVES OF SOBETIROME | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2019-08-22 | — | — | WO | disclosed |
| WO-2019160980-A1 | DERIVATIVES OF SOBETIROME | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2019-08-22 | — | — | WO | disclosed |
| US-20190210950-A1 | DERIVATIVES OF SOBETIROME | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2019-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200325092-A1 | DERIVATIVES OF SOBETIROME | SNCA, SLC6A3, SLC6A1 | PSEN1 47/4885PSEN2 14/4885APH1B 3326/4885 |
| US-20210002208-A1 | DERIVATIVES OF SOBETIROME | SLC6A3, TPH1, SLC6A2 | PSEN1 145/4885PSEN2 199/4885APH1B 4561/4885 |
| US-20190210950-A1 | DERIVATIVES OF SOBETIROME | SNCA, SLC6A3, SLC6A1 | PSEN1 47/4885PSEN2 14/4885APH1B 3326/4885 |
| US-20240425437-A1 | DERIVATIVES OF SOBETIROME | SNCA, SLC6A3, SLC6A1 | PSEN1 47/4885PSEN2 14/4885APH1B 3326/4885 |
| US-10544075-B2 | Derivatives of sobetirome | SNCA, SLC6A3, SLC6A1 | PSEN1 47/4885PSEN2 14/4885APH1B 3326/4885 |
| US-11578032-B2 | Derivatives of sobetirome | SLC6A3, TPH1, SLC6A2 | PSEN1 145/4885PSEN2 199/4885APH1B 4561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.