Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 18/20 | 0.84 |
| ▸ | PTGDR | Q13258 | 7/20 | 0.84 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.66 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.66 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.66 |
| ▸ | PTGFR | P43088 | 1/20 | 0.66 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.66 |
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL2109494 | 0.92 | PTGER4 (0.72) | PTGER4PTGDRPTGER2TBXA2RPTGER1 | |
| SCHEMBL10019020 | 0.92 | PTGER4 (1.00) | PTGER4PTGDRPTGER2TBXA2RPTGER1 | |
| SCHEMBL2111190 | 0.91 | PTGER4 (0.98) | PTGER4PTGDRPTGER2TBXA2RPTGER1 | |
| SCHEMBL10050711 | 0.87 | PTGER4 (0.80) | PTGER4PTGDRPTGER2TBXA2RPTGER1 | |
| SCHEMBL10019023 | 0.84 | PTGER4 (0.85) | PTGER4PTGDRPTGER2TBXA2RPTGER1 | |
| SCHEMBL2109496 | 0.83 | PTGER4 (0.84) | PTGER4PTGDRPTGER2TBXA2RPTGER1 | |
| SCHEMBL2108724 | 0.82 | PTGER4 (0.71) | PTGER4PTGDRPTGER2TBXA2RPTGER1 | |
| SCHEMBL31366898 | 0.81 | PTGER4 (0.80) | PTGER4PTGDRPTGER2TBXA2RPTGER1 | |
| SCHEMBL25376489 | 0.80 | PTGER4 (0.79) | PTGER4PTGDRPTGER2TBXA2RPTGER1 | |
| SCHEMBL31610949 | 0.80 | PTGER4 (0.69) | PTGER4PTGDRPTGER2TBXA2RPTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114877-B1 | INDOLE AND INDOLINE CYCLOPROPYL AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | MERCK CANADA INC (CA) | 2012-12-26 | — | — | EP | disclosed |
| US-8158671-B2 | Indole and indoline cyclopropyl amide derivatives as EP4 receptor antagonists | MERCK CANADA INC. (CA) | 2012-04-17 | — | — | US | disclosed |