Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 12/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 10/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.33 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26847970 | 0.84 | PPARD (0.33) | FDPS | |
| Tromethamine SCHEMBL6421313 | 0.78 | MEN1 (0.39) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| Tromethamine SCHEMBL439905 | 0.77 | MEN1 (0.42) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| Tromethamine SCHEMBL31404439 | 0.75 | S1PR1 (0.46) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| Tromethamine SCHEMBL22231513 | 0.73 | MEN1 (0.37) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| Tromethamine SCHEMBL31404437 | 0.72 | MEN1 (0.50) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| Tromethamine SCHEMBL21111787 | 0.70 | MEN1 (0.39) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL9425272 | 0.70 | MEN1 (0.48) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| SCHEMBL28291034 | 0.70 | PPARD (0.32) | — | |
| Phosphoric Acid SCHEMBL10727717 | 0.69 | PPARD (0.37) | MEN1KMT2AFDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116135948-A | Chemical etching composition and application thereof | 安集微电子（上海）有限公司 | 2023-05-19 | — | — | CN | claimed |
| CN-115911555-A | Sodium ion battery electrolyte | 中国科学院化学研究所 | 2023-04-04 | — | — | CN | claimed |
| CN-115584263-A | Chemical etching composition and application thereof | 安集微电子（上海）有限公司 | 2023-01-10 | — | — | CN | claimed |
| CN-111801833-B | Nonaqueous electrolyte and energy device using same | 三菱化学株式会社 | 2024-07-16 | — | — | CN | disclosed |
| CN-112136242-B | Electrolyte, electrochemical device, lithium ion secondary battery and assembly | 大金工业株式会社 | 2024-03-08 | — | — | CN | disclosed |
| CN-111788733-B | Nonaqueous electrolyte and power storage device using same | 三菱化学株式会社 | 2024-02-02 | — | — | CN | disclosed |
| CN-116525945-A | Nonaqueous electrolyte solution and nonaqueous electrolyte secondary battery using same | 三菱化学株式会社 | 2023-08-01 | — | — | CN | disclosed |
| CN-116135948-A | Chemical etching composition and application thereof | 安集微电子（上海）有限公司 | 2023-05-19 | — | — | CN | disclosed |
| CN-115911555-A | Sodium ion battery electrolyte | 中国科学院化学研究所 | 2023-04-04 | — | — | CN | disclosed |
| CN-115584263-A | Chemical etching composition and application thereof | 安集微电子（上海）有限公司 | 2023-01-10 | — | — | CN | disclosed |
| CN-109496374-B | Electrolyte solution, electrochemical device, secondary battery, and module | 大金工业株式会社 | 2022-05-03 | — | — | CN | disclosed |
| CN-109643826-B | Electrolyte solution, electrochemical device, secondary battery, and module | 大金工业株式会社 | 2022-03-15 | — | — | CN | disclosed |
| CN-113903997-A | Electrolyte solution, electrochemical device, secondary battery, and module | 大金工业株式会社 | 2022-01-07 | — | — | CN | disclosed |
| CN-112136242-A | Electrolyte solution, electrochemical device, lithium ion secondary battery, and assembly | 大金工业株式会社 | 2020-12-25 | — | — | CN | disclosed |
| CN-111801833-A | Nonaqueous electrolyte solution and energy device using same | 三菱化学株式会社 | 2020-10-20 | — | — | CN | disclosed |
| CN-111788733-A | Nonaqueous electrolyte solution and electricity storage device using same | 三菱化学株式会社 | 2020-10-16 | — | — | CN | disclosed |
| CN-111066192-A | Nonaqueous electrolyte secondary battery | 三菱化学株式会社 | 2020-04-24 | — | — | CN | disclosed |
| US-20190214682-A1 | ELECTROLYTE SOLUTION, ELECTROCHEMICAL DEVICE, SECONDARY BATTERY, AND MODULE | DAIKIN INDUSTRIES, LTD. (JP) | 2019-07-11 | — | — | US | disclosed |