Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 16/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 16/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.33 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL22231513 | 0.82 | MEN1 (0.37) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| Tromethamine SCHEMBL6421313 | 0.80 | MEN1 (0.39) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| SCHEMBL437818 | 0.79 | — | — | |
| Tromethamine SCHEMBL31404437 | 0.78 | MEN1 (0.50) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| Tromethamine SCHEMBL21111892 | 0.77 | MEN1 (0.36) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| SCHEMBL28417042 | 0.77 | FDPS (0.37) | FDPS | |
| Tromethamine SCHEMBL9425272 | 0.76 | MEN1 (0.48) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| Tromethamine SCHEMBL7899122 | 0.74 | LMNA (0.67) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| Tromethamine SCHEMBL1509014 | 0.74 | LMNA (0.67) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| Tromethamine SCHEMBL11761781 | 0.72 | MEN1 (0.43) | MEN1LMNAKMT2AS1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1765 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122073261-A | Electrolyte additive, electrolyte and battery | 广州天赐高新材料股份有限公司 | 2026-05-22 | — | — | CN | claimed |
| CN-122051359-A | Polymer electrolyte and contain this sodium ion battery of polymer electrolyte | 浙江钠创新能源有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122051388-A | Electrolyte, lithium secondary battery, and method for forming lithium secondary battery | 北京卫蓝新能源科技股份有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122025807-A | Secondary battery, battery module, battery pack, and power consumption device | 宁德时代新能源科技股份有限公司 | 2026-05-12 | — | — | CN | claimed |
| US-20260112698-A1 | Lithium Secondary Battery | LG ENERGY SOLUTION, LTD. (KR) | 2026-04-23 | — | — | US | claimed |
| CN-121583784-A | Electrolyte capable of inhibiting decomposition of super capacitor binder, and preparation method and application thereof | 今朝时代(安徽)新能源科技有限公司 | 2026-02-27 | — | — | CN | claimed |
| US-20250391917-A1 | ELECTROLYTE, BATTERY, AND ELECTRIC DEVICE | CONTEMPORARY AMPEREX TECHNOLOGY CO LTD (CN) | 2025-12-25 | — | — | US | claimed |
| US-20250266446-A1 | LITHIUM ION BATTERY | SHENZHEN CAPCHEM TECHNOLOGY CO., LTD. (CN) | 2025-08-21 | — | — | US | claimed |
| EP-4595143-A1 | TERNARY SOLVENT ELECTROLYTES FOR HIGH VOLTAGE AND HIGH RATE LITHIUM BATTERIES | Sepion Technologies, Inc. (US) | 2025-08-06 | — | — | EP | claimed |
| CN-120199893-A | Electrolyte additive composition, nonaqueous electrolyte containing same and secondary battery | 深圳市研一新材料有限责任公司 | 2025-06-24 | — | — | CN | claimed |
| CN-110870126-A | Electrolyte for lithium battery and lithium battery including the same | 三星SDI株式会社 | 2020-03-06 | — | — | CN | claimed |
| CN-110854433-A | Electrolyte and electrochemical device | 欣旺达电动汽车电池有限公司 | 2020-02-28 | — | — | CN | claimed |
| CN-110746554-A | Film forming agent and application thereof in semi-inorganic insulating coating liquid for silicon steel | 常州广树化工科技有限公司 | 2020-02-04 | — | — | CN | claimed |
| US-10541138-B2 | Diffusing agent composition and method of manufacturing semiconductor substrate | TOKYO OHKA KOGYO CO., LTD. (JP) | 2020-01-21 | — | — | US | claimed |
| CN-110707358-A | Electrolyte for high-voltage lithium ion battery | 中国科学院福建物质结构研究所 | 2020-01-17 | — | — | CN | claimed |
| CN-110627830-A | Disodium p-nitrophenylphosphate and preparation method thereof | 安徽昊帆生物有限公司 | 2019-12-31 | — | — | CN | claimed |
| US-20190043724-A1 | DIFFUSING AGENT COMPOSITION AND METHOD OF MANUFACTURING SEMICONDUCTOR SUBSTRATE | TOKYO OHKA KOGYO CO., LTD. (JP) | 2019-02-07 | — | — | US | claimed |
| EP-1585142-A1 | Composition for electrolyte, high molecular weight electrolyte, and battery using it | SONY CORPORATION (JP) | 2005-10-12 | — | — | EP | claimed |
| EP-1050916-A1 | Phosphate additives for nonaqueous electrolyte in rechargeable electrochemical cells | WILSON GREATBATCH LTD. (US) | 2000-11-08 | — | — | EP | claimed |
| US-6093780-A | CONSISTS OF ALPHA-CYANOACRYLATE AND A THERMAL RESISTANCE CONFERRING COMPONENT SELECTED FROM THE ALKYLATING AGENT SUCH AS 4-NITROBENZYL CHLORIDE OR POLYVINYL BENZYL CHLORIDE AND A SILYLATING AGENT | LOCTITE CORPORATION (US) | 2000-07-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260112698-A1 | Lithium Secondary Battery | SCN2B, KCNN2, KCNN3 | MEN1 438/4885LMNA 1029/4885KMT2A 1125/4885 |
| US-20250391917-A1 | ELECTROLYTE, BATTERY, AND ELECTRIC DEVICE | ATP5PO, CACNA2D3, SIK3 | MEN1 4719/4885LMNA 3411/4885KMT2A 3655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.