Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28672311 | 0.83 | — | — | |
| Tromethamine SCHEMBL21224900 | 0.80 | MEN1 (0.42) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL6416973 | 0.76 | MEN1 (0.42) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL442155 | 0.75 | MEN1 (0.46) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL21111892 | 0.70 | MEN1 (0.36) | MEN1LMNAKMT2A | |
| SCHEMBL28933732 | 0.69 | — | — | |
| Tromethamine SCHEMBL21111803 | 0.69 | MEN1 (0.39) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL21111811 | 0.69 | MEN1 (0.34) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL5428915 | 0.67 | MEN1 (0.59) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL571834 | 0.65 | MEN1 (0.77) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116135948-A | Chemical etching composition and application thereof | 安集微电子（上海）有限公司 | 2023-05-19 | — | — | CN | claimed |
| CN-115584263-A | Chemical etching composition and application thereof | 安集微电子（上海）有限公司 | 2023-01-10 | — | — | CN | claimed |
| CN-113903997-B | Electrolyte, electrochemical device, secondary battery, and assembly | 大金工业株式会社 | 2024-08-30 | — | — | CN | disclosed |
| CN-111801833-B | Nonaqueous electrolyte and energy device using same | 三菱化学株式会社 | 2024-07-16 | — | — | CN | disclosed |
| CN-111788733-B | Nonaqueous electrolyte and power storage device using same | 三菱化学株式会社 | 2024-02-02 | — | — | CN | disclosed |
| CN-116525945-A | Nonaqueous electrolyte solution and nonaqueous electrolyte secondary battery using same | 三菱化学株式会社 | 2023-08-01 | — | — | CN | disclosed |
| CN-116135948-A | Chemical etching composition and application thereof | 安集微电子（上海）有限公司 | 2023-05-19 | — | — | CN | disclosed |
| CN-112803067-B | Electrolyte and lithium secondary battery comprising same | 广州天赐高新材料股份有限公司 | 2023-02-24 | — | — | CN | disclosed |
| CN-115584263-A | Chemical etching composition and application thereof | 安集微电子（上海）有限公司 | 2023-01-10 | — | — | CN | disclosed |
| CN-109496374-B | Electrolyte solution, electrochemical device, secondary battery, and module | 大金工业株式会社 | 2022-05-03 | — | — | CN | disclosed |
| CN-110212235-B | Lithium secondary battery electrolyte capable of reducing battery impedance and lithium secondary battery thereof | 广州天赐高新材料股份有限公司 | 2022-04-08 | — | — | CN | disclosed |
| CN-109643826-B | Electrolyte solution, electrochemical device, secondary battery, and module | 大金工业株式会社 | 2022-03-15 | — | — | CN | disclosed |
| CN-113903997-A | Electrolyte solution, electrochemical device, secondary battery, and module | 大金工业株式会社 | 2022-01-07 | — | — | CN | disclosed |
| CN-112803067-A | Electrolyte and lithium secondary battery comprising same | 广州天赐高新材料股份有限公司 | 2021-05-14 | — | — | CN | disclosed |
| CN-111801833-A | Nonaqueous electrolyte solution and energy device using same | 三菱化学株式会社 | 2020-10-20 | — | — | CN | disclosed |
| CN-111788733-A | Nonaqueous electrolyte solution and electricity storage device using same | 三菱化学株式会社 | 2020-10-16 | — | — | CN | disclosed |
| CN-111066192-A | Nonaqueous electrolyte secondary battery | 三菱化学株式会社 | 2020-04-24 | — | — | CN | disclosed |
| US-20190214682-A1 | ELECTROLYTE SOLUTION, ELECTROCHEMICAL DEVICE, SECONDARY BATTERY, AND MODULE | DAIKIN INDUSTRIES, LTD. (JP) | 2019-07-11 | — | — | US | disclosed |