Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22612074 | 1.00 | CA1 (0.39) | CA1CA2HAO1CES2CES1 | |
| SCHEMBL21112252 | 1.00 | CA1 (0.39) | CA1CA2HAO1CES2CES1 | |
| SCHEMBL21112254 | 1.00 | CA1 (0.39) | CA1CA2HAO1CES2CES1 | |
| SCHEMBL28890374 | 0.80 | ALDH1A1 (0.37) | CA1CA2CES2CES1HPGD | |
| SCHEMBL29640184 | 0.80 | ALDH1A1 (0.37) | CA1CA2CES2CES1HPGD | |
| SCHEMBL29457193 | 0.80 | ALDH1A1 (0.37) | CA1CA2CES2CES1HPGD | |
| SCHEMBL17688704 | 0.79 | RAB9A (0.39) | HAO1HPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL17688702 | 0.79 | RAB9A (0.39) | HAO1HPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL15124899 | 0.77 | DGAT1 (0.35) | CES2CYP1A2HPGDLMNAALDH1A1 | |
| SCHEMBL15124897 | 0.77 | DGAT1 (0.35) | CES2CYP1A2HPGDLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3694846-B1 | 1-BENZYL-2-IMINO-4-PHENYL-5-OXOIMIDAZOLIDINE DERIVATIVES AS HIV PROTEASE INHIBITORS | GILEAD SCIENCES INC (US) | 2024-05-08 | — | — | EP | disclosed |
| US-11352329-B2 | HIV protease inhibitors | GILEAD SCIENCES, INC. (US) | 2022-06-07 | — | — | US | disclosed |
| US-11318119-B2 | HIV protease inhibitors | GILEAD SCIENCES, INC. (US) | 2022-05-03 | — | — | US | disclosed |
| US-20210078959-A1 | HIV PROTEASE INHIBITORS | GILEAD SCIENCES, INC. | 2021-03-18 | — | — | US | disclosed |
| US-20200345699-A1 | HIV PROTEASE INHIBITORS | GILEAD SCIENCES, INC. | 2020-11-05 | — | — | US | disclosed |
| US-10774053-B2 | HIV protease inhibitors | GILEAD SCIENCES, INC. (US) | 2020-09-15 | — | — | US | disclosed |
| US-20190210978-A1 | HIV PROTEASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2019-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210078959-A1 | HIV PROTEASE INHIBITORS | PRSS1, SERPINB1, FURIN | CA1 2034/4885CA2 1635/4885HAO1 3177/4885 |
| US-20200345699-A1 | HIV PROTEASE INHIBITORS | ACE, PRSS1, TMPRSS2 | CA1 2057/4885CA2 1024/4885HAO1 1723/4885 |
| US-10774053-B2 | HIV protease inhibitors | PRSS1, SERPINB1, FURIN | CA1 2034/4885CA2 1635/4885HAO1 3177/4885 |
| US-11352329-B2 | HIV protease inhibitors | PRSS1, SERPINB1, FURIN | CA1 2034/4885CA2 1635/4885HAO1 3177/4885 |
| US-20190210978-A1 | HIV PROTEASE INHIBITORS | PRSS1, SERPINB1, HPN | CA1 1598/4885CA2 1324/4885HAO1 1599/4885 |
| US-11318119-B2 | HIV protease inhibitors | ACE, PRSS1, TMPRSS2 | CA1 2057/4885CA2 1024/4885HAO1 1723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.